Xigduo XR (Dapagliflozin/Metformin Hcl) from Maple Leaf Medications.

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Formulation : ER Tablet
Drug Name Dosage Quantity Price Buy Now
Xigduo XR 5/1000mg 56 $97.00 Add To Cart
Xigduo XR 5/1000mg 112 $181.00 Add To Cart
Xigduo XR 10/500mg 28 $65.00 Add To Cart
Xigduo XR 10/1000mg 84 $248.00 Add To Cart
Xigduo XR
Dosage: 5/1000mg
Quantity: 56
Price: $97.00
Xigduo XR
Dosage: 5/1000mg
Quantity: 112
Price: $181.00
Xigduo XR
Dosage: 10/500mg
Quantity: 28
Price: $65.00
Xigduo XR
Dosage: 10/1000mg
Quantity: 84
Price: $248.00

Xigduo XR Uses

Xigduo XR, with the generic name dapagliflozin & metformin hydrochloride, is an oral medication indicated to treat high blood sugar levels or improve glycemic control among adults with type 2 diabetes mellitus. This is usually given as an adjunct to diet and exercise. This medication is not a treatment for diabetic ketoacidosis and types 1 diabetes mellitus.

This is available in Xigduo XR 10 mg/ 1000 mg, 10 mg/500 mg, 5 mg/500 mg, 2.5 mg/1000 mg, and Xigduo XR 5/ 1000 mg.

Xigduo Mechanism of Action

This extended-release tablet contains a sodium-glucose cotransporter 2 (SGLT2) inhibitor as well as a biguanide. This drug works by reducing the reabsorption of filtered glucose and lowering the threshold of glucose in the kidney, thereby increasing the glucose excretion in the urine. It also reduces hepatic glucose synthesis and intestinal glucose absorption while increasing insulin sensitivity by increasing peripheral glucose uptake and utilization.

How to use Xigduo XR

Read the medicine information sheet that comes with this product first. Avoid taking this maintenance drug without fully understanding the instructions and drug information written in the guide. If you need further medical advice on your condition or have any inquiries about using this prescription drug, you may ask your doctor or pharmacist.

Take the extended-release tablet orally. This is usually prescribed once daily. It is best to take the drug in the morning, with food. Swallow the tablet whole and drink a glass of water right after. Do not crush, divide, or chew the medicine, for doing so can release the active ingredients all at once, increasing the risk of adverse effects.

Remember to take this antidiabetic agent regularly and exactly as directed. Make a dosing schedule to avoid missing your doses. Do not change your Xigduo XR dosage as it will depend on your laboratory results, medical condition, response to medication, and other medications you are taking. You should also keep taking this drug even when you feel better. Do not stop taking it abruptly to prevent worsening conditions.

This oral drug is only a part of an entire treatment plan. To achieve the full benefits of the medication, you must comply with the physician’s recommended diet and exercise. Always eat a well-balanced meal and exercise regularly.

Xigduo XR Side Effects

Common side effects:

  • Nausea
  • Headache
  • Dizziness
  • Runny nose
  • Diarrhea
  • Constipation
  • Stomach pain

Mostly, the side effects caused by this diabetes drug are mild and temporary. If the adverse reactions get worse or do not resolve even after a while, you may have to hold this drug and consult your doctor or any healthcare professional. Further, you must also report severe side effects, such as:

  • Urinary tract infection
  • Changes in urine output
  • Yeast infection in the vagina or penis
  • Low blood sugar or hypoglycemia
  • High blood sugar or hyperglycemia
  • Dehydration

This is not a full or complete list of the side effects of Xigduo XR.

Precautions when using Xigduo XR

Before starting to use this oral antidiabetic agent, you must fully disclose your medical history to your doctor, including blood problems, severe dehydration, heart disease, kidney disease, liver disease, breathing problems, and alcohol abuse. Some conditions may significantly impact how your body will respond to treatment. Additionally, you should talk about all the supplements, prescription drugs, nonprescription drugs, and herbal products you are taking due to possible drug interactions.

Be watchful for an allergic reaction while taking this oral medication. Do not take this extended-release drug if you have a known allergy to dapagliflozin, metformin, or any inactive ingredients each tablet may contain. Alert your local emergency line immediately once you encounter signs of hypersensitivity, such as skin rashes, swelling, hives, severe dizziness, and breathing difficulty.

This medication may interact with alcohol and cause lactic acidosis, high ketone level, and low blood sugar levels. Alcohol can also trigger or worsen certain side effects, such as headaches and dizziness. With this, you must limit or avoid drinking alcoholic beverages.

Always stay hydrated and avoid taking water pills or diuretics as much as possible. Too much sweating, vomiting, diarrhea, and high fever could lead to dehydration, further increasing the risk of lactic acidosis.

Pregnancy could cause diabetes or worsen the condition. Consult your healthcare provider about your condition for changes in treatment or drug of choice might be necessary.

Frequently Asked Questions

Is Xigduo XR prescribed to children?

It is still unknown whether this diabetes treatment is safe and effective for children.

What is Xigduo XR used for?

This extended-release tablet is used to manage type 2 diabetes.

Can Xigduo XR cause weight loss?

Any weight change is not a common adverse effect of this medication.

Does this medication cause depression or any mood changes?

There is no direct link between Xigduo XR & depression.

Do I need a doctor’s prescription to buy Xigduo XR (dapagliflozin, metformin HCl)?

Yes, you need a prescription from your physician to purchase this antidiabetic drug.

Brand Name:

Xigduo XR

Scientific Name:

Dapagliflozin/Metformin Hcl

Other Names:

Xigduo XR


5/1000mg, 10/500mg, 10/1000mg

Quantities Available:

28, 56, 84, 112


ER Tablet

Maple Leaf Medications has provided information from third parties intended to increase awareness and does not contain all the information about Xigduo XR (Dapagliflozin/Metformin Hcl). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Xigduo XR (Dapagliflozin/Metformin Hcl).