Janumet (Sitagliptin/Metformin) from Maple Leaf Medications.

Janumet (sitagliptin and metformin) Indications

Janumet, generic name sitagliptin and metformin, is an oral prescription tablet used to improve blood sugar control of people with type 2 diabetes mellitus (T2DM). This medication is used if treatment with sitagliptin and metformin is necessary. Janumet medication should be used in conjunction with proper diet and regular exercise.

Janumet is not indicated for type 1 diabetes mellitus or diabetic ketoacidosis. Janumet is not recommended as treatment for people with a history of pancreatitis or renal dysfunction.

Janumet is classified as a combination of a dipeptidyl peptidase-4 (DPP-4) inhibitor and a biguanide. It increases the insulin produced by the pancreas while decreasing the glucose produced by the liver. Janumet also improves insulin sensitivity and decreases the amount of glucose absorbed in the intestines.

Janumet (sitagliptin and metformin) Uses and Dosage

Please read the patient information guide before using Janumet.

Use Janumet exactly as prescribed by your doctor. Janumet is approved to be given two times daily at equal intervals (for example, 8AM and 8PM) at the same time every day. Take this medication for as long as it is prescribed and do not discontinue without your doctor’s approval.

Janumet should be taken by mouth with a glass of water and a meal. Do not break, cut, chew, crush, or divide this medication. This tablet should be swallowed whole with plenty of water and food.

Janumet (sitagliptin and metformin) Side Effects

Some common side effects of taking Janumet may include:

• Headache
• Nausea
• Vomiting
• Metallic taste in the mouth
• Stomach upset
• Diarrhea
• Weakness

If any of these side effects last too long or worsen, then please tell your doctor.

Serious Side Effects

Some of the severe side effects of Janumet may include:

• Low blood sugar
• High blood sugar
• Changes in the amount of urine
• Joint pain
• Unusual skin blisters
• Shortness of breath
• Swelling of the ankles and feet
• Sudden weight gain
• Unusual tiredness
• Severe abdominal pain
• Persistent nausea and vomiting
• Loss of appetite

These adverse reactions should be reported to your doctor immediately.

Allergic Reactions

Do not use Janumet if you have a known allergy to sitagliptin, metformin, or the other inactive ingredients in this medication. Seek emergency assistance if an allergy develops while using this prescription medication. Signs of an allergy include:

• Hives
• Itching
• Rashes
• Severe dizziness
• Swelling of the face and neck
• Trouble breathing
• Wheezing
• Swollen lymph nodes

Janumet (sitagliptin and metformin) Cautions

Janumet for T2DM may not be used in people who have any history of:

• Severe asthma
• Chronic obstructive pulmonary disease
• Anemia
• Vitamin B12 deficiency
• Pancreatitis
• Gallbladder disease
• Liver disorders
• Kidney disease

Janumet contains metformin, which can affect the menstrual cycle. Metformin can improve ovulation and increase the risk of getting pregnant, therefore, use birth control methods if necessary.

Janumet should only be used during pregnancy when the benefits outweigh the risks. Your physician may advise other T2DM treatments that are safer for the unborn baby.

Metformin can pass through breast milk, yet it is unknown whether sitagliptin does. Therefore, it is necessary to consult your doctor before taking Janumet when preparing to breastfeed.

Janumet (sitagliptin and metformin) Form and Strength

Janumet oral prescription is available in the following strengths:

• Janumet, tablets
  • 50/500 mg
  • 50/850 mg
  • 50/1000 mg

FAQ

Is Janumet stronger than metformin?

Janumet is more effective than taking metformin alone. It can start working within four to five days of regular use.

Does Janumet cause weight gain?

Taking Janumet does not usually cause weight gain, yet any medication containing metformin may cause weight loss.

Can I take Janumet without food?

Janumet is best taken with a meal and full glass of water. If it is taken on an empty stomach, it may cause stomach upset.

Can you drink alcohol while taking Janumet?

Those who are taking Janumet should avoid beverages that contain alcohol. Alcohol can cause hypoglycemia and may increase the risk of developing high lactic acid levels.

Resources

https://www.goodrx.com/janumet/what-is

https://www.janumetxr.com/

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022044s022lbl.pdf

https://www.webmd.com/drugs/2/drug-148074/janumet-oral/details

https://www.rxlist.com/janumet-side-effects-drug-center.htm