Estring (Estradiol Hemihydrate) from Maple Leaf Medications.

We don't sell this generic-version medication.

( Top Brand Option )

Price Match See Generic Alternative to (Estring) Pricing Below.

Buy Brand Estring

Prescription Prescription Required
Formulation : Vaginal Ring
Drug Name Dosage Quantity Price Buy Now
Estring 2mg 1 $578.00 Add To Cart
Dosage: 2mg
Quantity: 1
Price: $578.00

What is Estring (Estradiol Hemihydrate)?

Estring is a vaginal ring with the generic name estradiol hemihydrate. Estring medication is classified as an estrogen derivative.

This soft, flexible ring is used for the treatment of moderate vaginal symptoms of menopause, such as vaginal atrophy, dyspareunia, and pruritus. Estring vaginal ring can also treat urinary symptoms like painful urination and frequent urges to urinate.

To date, there are no available Estring generic alternatives. Use this product only if prescribed by a physician.

How to Use Estring (Estradiol Hemihydrate)

Read the Estring instructions and medication guide before using this prescription medication. You may use this product for other Estring uses only if recommended by the doctor.

This vaginal ring is good for three months or ninety days. Do not leave it for longer than ninety days. Always follow your dosing schedule as advised by your doctor.

Step-by-Step Estring Directions:

  1. Wash your hands and remove the vaginal ring from the packaging.
  2. Hold Estring using your thumb and index fingers. Then, press the opposite sides of the ring together.
  3. Push the ring gently into the upper third of the vagina. If it feels uncomfortable, this may mean that the ring is not far enough.
  4. For Estring removal, loop your finger through the vaginal ring and pull it out carefully. Make sure to wash your hands before doing this.

Side Effects of Estring (Estradiol Hemihydrate)

Here are the common and less serious Estring side effects:

  • Irregular vaginal bleeding or spotting
  • Increased vaginal discharge without bad odor
  • Abdominal cramps
  • Bloating
  • Breast pain
  • Headache
  • Nausea
  • Vomiting
  • Fluid retention
  • Vaginal yeast infection

Using this ring may also cause insomnia, back pain, and hot flashes. In addition, there is a known association between Estring and weight loss or gain.

Serious Side Effects:

Before using this vaginal ring, women are advised regarding the severe but rare side effects they may experience. Contact your physician right away if you experience these side effects:

  • Breast lumps
  • Unusual vaginal bleeding
  • Changes in vision
  • Severe headache
  • Memory loss
  • Confusion
  • High blood pressure
  • Signs of blood clots
  • Signs of fibroids
  • Dementia

Allergic Reactions

Women with known allergies to Estradiol, silicone polymers, and barium sulfate should not use this medication. Call for emergency help right away if you notice signs of allergic reaction, such as:

  • Rash
  • Hives
  • Itching
  • Wheezing
  • Chest tightness
  • Trouble breathing
  • Unusual hoarseness
  • Swelling of the mouth, face, and throat

Estring (Estradiol Hemihydrate) Precautions

Using this vaginal ring can be contraindicated for women with the following conditions or medical history:

  • Cardiovascular disorder
    • Coronary heart disease
    • Stroke
    • Venous thromboembolism
  • Malignant neoplasms
    • Endometrial cancer
    • Breast cancer
    • Ovarian cancer
  • Probable dementia
  • Gallbladder disease
  • Hereditary angioedema
  • Hypercalcemia
  • Vision problems

In addition, using this prescription may aggravate or exacerbate some conditions. Other Estring precautions that you should take note of are:

  • Elevated blood pressure
  • High levels of cholesterol
  • Hypothyroidism
  • Liver disease
  • Low levels of calcium
  • Endometriosis
  • Asthma
  • Diabetes Mellitus
  • Migraine
  • Systemic lupus erythematosus
  • Hepatic hemangioma
  • Vaginal infection

Avoid smoking and using tobacco while on Estradiol. Nicotine can increase the risk of hypertension, stroke, blood clots, and myocardial infarction.

This prescription may cause photosensitivity. Exposure to the sun may cause dark, blotchy patches on the skin, especially on the face. Avoid prolonged sun exposure and always wear sunscreen.

Continuous and long-term use of this vaginal ring may cay cause:

  • Breast carcinoma
  • Testes carcinoma
  • Vaginal carcinoma
  • Uterine cancer
  • Cervical cancer
  • Liver cancer

This type of vaginal medication should not be used during pregnancy and lactation.

Buy Estring (Estradiol Hemihydrate) Online

You may buy Estring vaginal ring from various drugstores, including online pharmacies. Recently, many people have opted to buy Estring online because of the convenience that online pharmacies can offer.

Buying Estring (Canadian pharmacy) in Canada is safe and easy. You may check the availability and prices of all medications you need and process your orders through the website. Online Canadian pharmacies are being regulated by the government.

The prices of medications available in online Canadian pharmacies are much lower compared to the prices in traditional drugstores in other countries. You can save 30% up to 70% on your prescription. For more information on Estring cost (Canada), you may check the price details above.

Estring Form and Strength

You may purchase Estring in the following forms and strengths:

  • Estring vaginal ring
    • 2 mg


Where should I keep my medication?

This vaginal ring can be kept in the bathroom cabinet or anywhere convenient. Make sure to place it at room temperature, 59°F to 77°F (15°C-25°C). Do not place it near direct heat.

Do I need a prescription for Estring?

A prescription is required when purchasing this vaginal medication.

Can Estring fall out?

Although rare, Estring may fall out due to intense coughing and straining. If this happens, wash the vaginal ring properly and reinsert it.

Is Estring safe for long-term use?

You must use this prescription medication only for as long as needed or prescribed. Prolonged use of this vaginal ring would put you at greater risk of developing serious adverse effects.



Brand Name:


Scientific Name:

Estradiol Hemihydrate

Other Names:




Quantities Available:



Vaginal Ring

Maple Leaf Medications has provided information from third parties intended to increase awareness and does not contain all the information about Estring (Estradiol Hemihydrate). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Estring (Estradiol Hemihydrate).