Minivelle (Estradiol Transdermal System) from Maple Leaf Medications.

Prescription Prescription Required
Formulation : Patch
Drug Name Dosage Quantity Price Buy Now
Minivelle 0.05mg 8 $225.00 Add To Cart
Minivelle 0.05mg 24 $652.00 Add To Cart
Minivelle 0.025mg 8 $226.00 Add To Cart
Minivelle 0.025mg 24 $652.00 Add To Cart
Minivelle 0.075mg 8 $225.00 Add To Cart
Dosage: 0.05mg
Quantity: 8
Price: $225.00
Dosage: 0.05mg
Quantity: 24
Price: $652.00
Dosage: 0.025mg
Quantity: 8
Price: $226.00
Dosage: 0.025mg
Quantity: 24
Price: $652.00
Dosage: 0.075mg
Quantity: 8
Price: $225.00

( Affordable Generic Alternatives )

Buy Estradiol Transdermal System Estradiol Transdermal System

Prescription Prescription Required
Formulation : Patch
Drug Name Dosage Quantity Price Buy Now
Estradiol Transdermal System 0.05mg 8 $115.00 Add To Cart
Estradiol Transdermal System
Dosage: 0.05mg
Quantity: 8
Price: $115.00


What is Minivelle? 

The transdermal system Minivelle, with the generic name estradiol, treats moderate to severe vasomotor symptoms linked to menopause. These symptoms are caused by the constriction or dilation of the blood vessels. These include hot flashes, changes in blood pressure, palpitations, flushes, and night sweats. This is also being prescribed to prevent postmenopausal osteoporosis. 

This is available in Minivelle 0.1 mg patch, 0.075 mg patch, 0.05 mg patch, and 0.0375 mg patch. 

How does Minivelle work? 

Estradiol is known as the principal intracellular form of estrogen in humans and is more powerful than estrone and estriol. This medication helps in developing and maintaining the female reproductive system and secondary sexual characteristics. Through the negative feedback mechanism, it could also help in modulating the pituitary secretion of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and gonadotropins. When the elevated concentration of these hormones is reduced, postmenopausal symptoms are addressed. 

How to use Minivelle Patch 

To initiate, read the Minivelle information leaflet that comes with this product. Do not use any medicated patch if you have not yet fully understood all drug information and instructions in the guide provided. If you need more medical advice regarding your symptoms or if you have inquiries related to this treatment, you can ask your doctor or pharmacist. 

Always make sure to apply the patch on a clean, dry area that is free of lotion, oil, or powder. This could be applied to different areas of the abdomen or buttocks. Note that you should not use the same application site twice in the same week and do not apply it to the area of the breast or around it.  

Peel the backing of the transdermal patch. Then, press it firmly for about 10 seconds to make sure that it will stay in place. This patch is usually replaced every three to four days or twice a week. Make a dosing schedule to avoid forgetting to apply a new patch. 

Remember to use this medication exactly as directed to achieve the full benefits. Do not alter your Minivelle dose as it is based on your medical condition and response to therapy. Also, you should keep using this drug for as long as prescribed to avoid rebound effects. 

Minivelle Patch Side Effects 

Common side effects: 

-Redness or irritation on the application site 




-Weight changes 


-Breast tenderness 



Mostly, the side effects caused by this medication are mild and will resolve on their own. However, if the adverse reactions become worse or persist, you should hold the transdermal patch and consult your doctor or any healthcare professional. You should also report severe side effects, like: 

-Symptoms of blood clots (chest pain, trouble breathing, coughing out blood, severe headache, confusion, vision changes, weakness on one side of the body) 

-Unusual vaginal bleeding 

-Breast lumps 

-Increased vaginal irritation 

-Severe abdominal pain 

-Dark urine 

-Persistent nausea and vomiting 

This is not a complete or full list of the side effects of Minivelle. 

Precautions when using Minivelle 

Before you start using this prescription patch, you should fully disclose your medical history to your doctor, especially certain cancers, vaginal bleeding of unknown cause, blood clots, stroke, heart attack, high blood pressure, high levels of cholesterol, diabetes, angioedema, liver disorders, kidney problems, hypothyroidism, hypoparathyroidism, mineral imbalance, hormone problems, porphyria, mental or mood changes, seizures, asthma, gallbladder disease, and migraine. Some conditions may impact how you will respond to the medication. You should also talk about all the prescription drugs, nonprescription drugs, and supplements you are taking because of the possible drug interactions. 

When taking this treatment, be on the lookout for allergic reactions. Do not use this prescription patch if you have a known allergy to estradiol or any inactive ingredients it may contain. Immediately discontinue the patch and seek emergency help once you notice signs of hypersensitivity, such as skin rashes, hives (itchiness), swelling of the face and neck, severe dizziness, and trouble breathing. 

Do not smoke, use tobacco or any substances that may contain nicotine. This is because nicotine could further increase the risk of blood clots, heart attack, stroke, and hypertension, particularly for women 35 years old and above. 

Talk to your healthcare provider if you are going to be confined in a certain position for an extended period of time. This situation includes going through hours of surgery or going on a long-haul flight. Limited movements for a long period may also increase the risk of blood clot formation. 

If you are undergoing an MRI procedure, tell your doctor about your patch. This transdermal system may contain metal that could cause serious burns during an MRI. Your doctor may ask you to take off your patch before the procedure and have it replaced right after. 

This patch may cause melasma, which is the dark, blotchy patches on the face or skin. To avoid worsening skin conditions, limit your sun exposure. You should also apply sunblock cream and wear protective clothing when going outdoors. 

Frequently Asked Questions 

What should I do if my patch falls off? 

If your patch falls off, replace it with a new one but change your patch as scheduled. 

What is the difference between Minivelle vs Vivelle Dot? 

Both patches have the same pharmacological effect. However, Minivelle is usually preferred because it is the smallest estrogen patch available. 

Does this patch cause weight gain? 

When it comes to adverse effects, there is a direct link between Minivelle Patch & weight gain.

Is it safe to use Minivelle Patch IVF?

Yes, this estradiol patch is also prescribed for those who will be undergoing an IVF procedure. 

How much does Minivelle cost? 

You may check for the prices of this patch from this page. 

Additional information

Drug Name:


Scientific Name:

Estradiol Transdermal System

Other Names:

Minivelle, Estradiol


0.05mg, 0.075mg, 0.025mg

Quantities Available:

8, 24



Maple Leaf Medications has provided information from third parties intended to increase awareness and does not contain all the information about Minivelle (Estradiol Transdermal System). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Minivelle (Estradiol Transdermal System).