Linzess (Linaclotide) from Maple Leaf Medications.

Linzess (linaclotide) Indications

Linzess, generic name linaclotide, is an oral prescription medication used for the treatment of irritable bowel syndrome with constipation. This oral medication improves the texture of the stool and reduces symptoms, such as abdominal discomfort, bloating, straining, and feelings of incomplete bowel movements.

Linzess is also prescribed for chronic idiopathic constipation. This bowel condition is characterized by infrequent, incomplete, or difficult defecation.

Linzess is classified as a guanylate cyclase-C agonist. It works by increasing the levels of intracellular and extracellular cyclic guanosine monophosphate, which expedites gastrointestinal transit.

Linzess (linaclotide) Uses and Dosage

Read the medication guide before taking Linzess.

Always administer Linzess exactly as prescribed by the doctor. Linzess is taken by mouth once daily with a glass of water 30 minutes before the first meal of the day. If unable to swallow the entire capsule, the contents can be mixed with water or a teaspoon of applesauce but make sure to take the mixture immediately. Do not change the prescribed dosage

Linzess (linaclotide) Side Effects

The common side effects of Linzess are:

• Abdominal pain or discomfort
• Bloating
• Gas
• Diarrhea

These side effects are usually  mild, yet if any persist or worsen please consult a healthcare professional.

Serious Side Effects

Although uncommon, severe adverse effects of Linzess are:

• Severe diarrhea
• Dehydration
• Severe abdominal pain

These adverse reactions should immediately be reported to your physician immediately.

Allergic Reactions

Do not take Linzess if you have an allergy to linaclotide or any ingredients that this product contains. Seek emergency assistance if an allergy develops while taking this medication. Signs of allergy include:

• Severe dizziness
• Rashes
• Hives
• Itching
• Swelling of the face and neck
• Wheezing
• Trouble breathing
• Swollen lymph nodes

Linzess (linaclotide) Cautions

Taking Linzess may be contraindicated in people with any stomach or intestinal blockage.

Consult your physician if you become pregnant prior to  or while taking Linzess . The effects of this medication on pregnancy are not fully known.

It has not been determined if the contents of Linzess can pass through breast milk. Breastfeeding women must know all the risks prior to using this medication.

Linzess (linaclotide) Form and Strength

Linzess is available in the following:

• Linzess, capsules
  • 72 mcg
  • 145 mcg
  • 290 mcg

FAQ

How quickly does Linzess make you defecate?

Linzess starts working as soon as the first dose is consumed. However, it may take a week for the constipation to be relieved.

Is Linzess a laxative or stool softener?

Linzess is not a laxative. It works by increasing the water and chloride in the intestines, which stimulates bowel movement as it softens the stool.

How long can you take Linzess?

There is no suggested limit on how long Linzess can be taken. Your physician will assess and evaluate how long this medication is to be taken based on the response.

Can I buy Linzess over the counter?

Linzess is a prescription-only product. You need a signed prescription from your doctor to purchase this medication.

Resources

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/202811s013lbl.pdf

https://www.webmd.com/drugs/2/drug-162895/linzess-oral/details