Glucovance, with the generic name glyburide & metformin hydrochloride, is an oral medication indicated to lower blood glucose levels among adults who have type 2 diabetes mellitus. This is given together with proper diet and exercise. By improving glycemic control,
Glucovance helps prevent complications of diabetes, such as nerve problems, sexual dysfunction, loss of limbs, kidney damage, blindness, heart attack, and stroke.
This is available in Glucovance 5/500 mg and 2.5/500 mg tablet forms.
Glucovance Mechanism of Action
This antidiabetic agent is a combination of sulfonylurea and biguanide. It works by stimulating insulin release from the pancreas, which is dependent on the functioning beta cells in the islets of the pancreas. This drug also lowers the production of hepatic glucose, decreases the absorption of glucose in the intestines, and increases insulin sensitivity through the increase of peripheral glucose uptake and utilization.
How to use Glucovance
To start, read the medication information leaflet that comes with this prescription drug. Do not take any diabetes drugs if you have not yet fully understood the doctor’s instructions and all drug information printed in the guide. If you have further queries about your drug of choice or need more medical advice, you can ask your doctor or pharmacist.
Take this tablet orally. This is usually prescribed twice daily or as directed by your doctor. This drug should be taken with food. Swallow the tablet whole and drink fluids thereafter. Cutting, crushing, or chewing this medication is not recommended.
Don’t forget to take this oral medication exactly as prescribed. Make a dosing schedule to achieve the best results and to avoid missing your doses. If you are also directed to take colesevelam, take this Glucovance medication at least 4 hours before this drug. This is because colesevelam can decrease the absorption of sulfonylureas.
Do not change your dosing or frequency as it is based on your medical condition, response to treatment, and other medications you are taking. Further, do not stop taking
This medication abruptly or even for a short period to avoid worsening conditions.
Please note that this antidiabetic drug is only an adjunct to proper diet and exercise. It is just as essential to comply with your other medications, eat healthy meals, and work out regularly. Make sure to follow your entire treatment plan.
Glucovance Side Effects
Common side effects:
In most cases, the common side effects caused by Glucovance are temporary and mild. However, if the adverse reactions do not get better or worse over time, you should hold this oral medicine and talk to your doctor or pharmacist. You should also report severe side effects, such as:
– Symptoms of an infection (fever, chills, persistent sore throat)
-Easy bruising and bleeding
-Severe abdominal pain
-Low blood sugar or hypoglycemia (dizziness, fast heartbeat, blurred vision, shaking, sweating, tingling sensation)
-High blood sugar or hyperglycemia (thirst, increased urination, fruity breath odor, confusion, rapid breathing, flushing)
This is not a complete or full list of the side effects of Glucovance.
Precautions when using Glucovance
Before you begin using this prescription drug, you should disclose your complete medical history to your physician, including serious infection, dehydration, poor circulation, liver disease, kidney disease, severe breathing problems, blood problems, hyponatremia, fertility problems, hormonal problems, thyroid disease, and autonomic neuropathy. Some conditions may directly affect how your body will respond to this diabetic medication. Moreover, you should talk about all prescription drugs, nonprescription drugs, supplements, and herbal products you are taking because of possible drug interactions.
While undergoing this therapy, keep an eye out for any allergic reactions. Avoid taking Glucovance if you have a known allergy to glyburide, metformin, or any inactive ingredients each tablet may contain. Discontinue medication and seek emergency help right away once you experience severe hypersensitivity. Signs of it are skin rashes, swelling, hives, severe dizziness, and trouble breathing.
This medication may increase the risk of lactic acidosis. Symptoms of lactic acidosis are respiratory distress, abdominal pain, sleepiness, myalgia, and malaise. The risk is higher for the elderly above the age of 65, people who drink alcohol excessively, and have liver problems. If you suspect lactic acidosis, consider it a medical emergency.
Alcohol may interact with glyburide and cause a disulfiram-like reaction. This could cause stomach pain, nausea, vomiting, dizziness, and facial flushing. Alcohol beverages can also trigger or worsen side effects like dizziness and drowsiness. You must practice extreme caution when driving, operating machinery, and doing activities that require clear vision and alertness.
You could be more reactive to the sun while taking this drug. Limit your sun exposure and do not do indoor tanning to avoid sunburn and skin blisters. You must apply sunscreen and wear protective clothing when going outdoors.
Because of the metformin component in Glucovance, it could cause menstrual changes. Metformin promotes ovulation and increases the risk of pregnancy. If necessary, talk to your healthcare provider about reliable birth control methods.
Pregnancy could cause or worsen your diabetes. This condition may require changes in your treatment plan. If you are breastfeeding, take this drug only if clearly necessary because some ingredients may pass into the breastmilk.
Frequently Asked Questions
Is Glucovance safe?
Yes, this antidiabetic drug is safe and effective.
Can I split the Glucovance tablet in half?
It is not recommended to cut this type of medication.
Does Glucovance cause dry mouth?
Dry mouth is not common while taking this drug.
How much is the Glucovance price?
You can check the prices of this medication from this page.
Is Glucovance and Glucophage the same?
No, the latter only contains metformin, while the former has both glyburide and metformin.
Glinil M, Glyburide/Metformin, Glucovance
Maple Leaf Medications has provided information from third parties intended to increase awareness and does not contain all the information about Glucovance (Glyburide/Metformin). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Glucovance (Glyburide/Metformin).