Glucotrol XL (Glipizide XL) from Maple Leaf Medications.

Prescription Prescription Required
Formulation : Extended Release Tablet
Drug Name Dosage Quantity Price Buy Now
Glucotrol XL 2.5mg 30 $80.00 Add To Cart
Glucotrol XL 2.5mg 90 $217.00 Add To Cart
Glucotrol XL 10mg 100 $107.00 Add To Cart
Glucotrol XL
Dosage: 2.5mg
Quantity: 30
Price: $80.00
Glucotrol XL
Dosage: 2.5mg
Quantity: 90
Price: $217.00
Glucotrol XL
Dosage: 10mg
Quantity: 100
Price: $107.00

( Affordable Generic Alternatives )

Buy Glipizide XL Glipizide XL

Prescription Prescription Required
Formulation : ER Tablet
Drug Name Dosage Quantity Price Buy Now
Glipizide Xl 2.5mg 90 $48.00 Add To Cart
Glipizide XL 10mg 90 $45.00 Add To Cart
Glipizide Xl
Dosage: 2.5mg
Quantity: 90
Price: $48.00
Glipizide XL
Dosage: 10mg
Quantity: 90
Price: $45.00

Glucotrol XL Uses 

Glucotrol XL, with the generic name glipizide, is an oral extended-release medication indicated to treat adults with type 2 diabetes mellitus, together with proper diet and exercise. It helps in improving glycemic control or decreasing high blood glucose levels. By controlling diabetes, complications like blindness, loss of limbs, sexual dysfunction, kidney damage, stroke, and heart attack can be prevented.  

This is available in Glucotrol XL 10 mg, 5 mg, and 2.5 mg extended-release tablets. 

Glucotrol XL Mechanism of Action 

This medication is classified as a sulfonylurea, which is an insulin secretagogue. It stimulates the release of insulin from the beta cells of the pancreas, which increases the plasma concentration of insulin. Apart from this, its blood glucose-lowering action involves increased peripheral glucose utilization by stimulating hepatic gluconeogenesis and increasing the sensitivity and number of insulin receptors. 

How to use Glucotrol XL 

To begin, read the medication guide or information leaflet that comes with this product. Avoid taking any antidiabetic agents without fully understanding the drug information and instructions written in the guide. If you have further inquiries on how this drug works or need additional medical advice, you can ask your doctor or pharmacist. 

Take this tablet orally. This is usually prescribed once daily. You should take it with breakfast or with your first meal of the day. Swallow the medication whole and drink a glass of fluid after. Avoid breaking, chewing, or crushing this tablet because doing so can release the active ingredient at one time, which could increase the risk of adverse effects. 

Remember to take this diabetes drug regularly and exactly as directed. Plan your doses beforehand to avoid forgetting them. s. If you are prescribed colesevelam, administer it at least 4 hours after taking this medication because colesevelam can decrease the absorption of glipizide. 

Do not alter your Glucotrol XL dosage as it is based on your medical condition, other drugs you are taking, and response to treatment. Also, you should not stop taking this medication abruptly or even for a short while to avoid worsening conditions. 

Note that this medication is only an adjunct to proper diet and work out. It is just as important to comply with the other parts of the treatment plan, including your other medications. Remember to eat a healthy, balanced meal at all times and to exercise regularly. 

Glucotrol XL Side Effects 

Common side effects: 






-Loss of appetite 

-Stomach upset 




-Weight gain 

Mostly, the side effects caused by this diabetes medication are mild and will resolve even without medical intervention. In case the adverse reactions worsen or persist, you should hold this medication and consult your doctor or any healthcare professional. Additionally, you must report severe side effects, such as: 

-Mental or mood changes 


-Severe fatigue 

-Swelling of the extremities 

-Easy bruising or blessing 

-Severe abdominal pain 

-Dark urine 

-Yellowish eyes and skin 

-Persistent vomiting 

-High blood sugar or hyperglycemia (flushing, fruity breath odor, palpitations, increased thirst, increased urination, confusion) 

-Low blood sugar or hypoglycemia (shaking, sweating, blurred vision, tingling sensation, dizziness) 

-Symptoms of infection (sore throat, fever, chills) 

This is not a full or complete list of the side effects of Glucotrol XL. 

Precautions when using Glucotrol XL 

Before starting to take this prescription drug, you should fully disclose your medical history to your physician, especially adrenal or pituitary insufficiency, SIADH, thyroid disease, hepatic impairment, kidney problems, electrolyte imbalance, or gastrointestinal problems. Certain conditions may significantly impact how your body will respond to the medication. Also, you should talk about all the prescription medication, nonprescription medication, supplements, and herbal products you are taking because they might have drug interactions with this sulfonylurea. 

While on this therapy, keep an eye out for any allergic reactions. Do not take this oral drug if you have a known allergy to glipizide or any inactive ingredients each tablet may contain. Signs of hypersensitivity include breathing difficulty, severe dizziness, skin rashes, hives, and swelling of the face and neck. If this happens, immediately discontinue the medication and call your local medical emergency hotline. 

Limit or avoid drinking alcohol while on glipizide. Alcohol drinks may lower blood sugar levels and increase the risk of hypoglycemia. It can also trigger certain adverse effects like dizziness and drowsiness. Moreover, you should practice safety precautions when driving, operating machinery, and doing activities that require alertness and clear vision. 

This diabetes drug may make you more sensitive to the sun, causing skin blisters or sunburn. Avoid indoor tanning and limit your sun exposure. When going outside, you should also apply sunscreen and wear protective clothing. 

Pregnancy may either cause or worsen diabetes. Talk to a health care provider regarding the possible changes in your treatment plan. If you are a breastfeeding mom, take this drug only if clearly needed. It is still unknown if this diabetes medication could pass into the breastmilk. 

Frequently Asked Questions 

Is Glucotrol XL also used for diabetic ketoacidosis? 

No, this is not prescribed for type 1 diabetes or diabetic ketoacidosis. 

What is the difference between Glucotrol and Glucotrol XL? 

The latter is an extended-release version of Glucotrol. 

Does Glucotrol XL make you feel sleepy? 

Yes, this drug causes drowsiness. 

How much does Glucotrol XL cost? 

You may check the prices of this oral medication from this page. 

Is Glucotrol XL an over-the-counter medication? 

This maintenance drug requires a valid prescription from your healthcare provider. 

Brand Name:

Glucotrol XL

Scientific Name:

Glipizide XL, Glipizide Xl

Other Names:

Glipizide Er, Glucotrol XL


2.5mg, 10mg

Quantities Available:

30, 90, 100


ER Tablet, Extended Release Tablet, Tablet

Maple Leaf Medications has provided information from third parties intended to increase awareness and does not contain all the information about Glucotrol XL (Glipizide XL). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Glucotrol XL (Glipizide XL).

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