Ampyra (Dalfampridine) from Maple Leaf Medications.

Ampyra (dalfampridine) Indications

Ampyra, generic name dalfampridine, is an oral prescription medication given to improve walking in adults with multiple sclerosis (MS). This improvement can be demonstrated by an increase in walking speed.

Ampyra is classified as a potassium channel blocker. The exact mechanism of action is unknown, yet it potentially increases the conduction action in demyelinated axons in the muscles by inhibiting potassium channels.

Ampyra (dalfampridine) Uses and Dosage

Read the medication guide before taking Ampyra.

Always take Ampyra exactly as prescribed. Ampyra is taken by mouth with a glass of water two times daily with or without food. Do not split, dissolve, crush, or chew the extended-release tablets. Avoid taking more than two pills in 24 hours and do not take two tablets at one time.

Ampyra (dalfampridine) Side Effects

Most of the side effects caused by Ampyra are mild. Some of the common side effects are:

• Urinary tract infections
• Insomnia or trouble sleeping
• Nausea
• Headache
• Dizziness
• Indigestion
• Constipation
• Diarrhea
• Balance problems

If these side effects persist or become worse, then please consult your healthcare provider.

Serious Side Effects

Some of the severe side effects of Ampyra are:

• Dysuria or painful urination
• Bloody urine
• Back pain
• Seizures
• Severe confusion
• Memory problems
• Worsening MS symptoms

These serious adverse reactions must be reported to the physician immediately.

Allergic Reactions

Do not take Ampyra potassium channel blocker if you have a known hypersensitivity to dalfampridine or other ingredients in this product. Seek emergency assistance if signs of an allergy develop while using this medication. Signs of an allergy include:

• Swelling of the face and neck
• Rashes
• Hives
• Itching
• Severe dizziness
• Swollen lymph nodes
• Wheezing
• Trouble breathing

Ampyra (dalfampridine) Cautions

Taking Ampyra may be contraindicated in patients with a history of:

• Seizures
• Kidney disease

Pregnant women must use Ampyra only if strongly advised by the doctor. The effects of this medication on fetal development have not been completely determined.

It is not known if the contents of Ampyra can be passed through to breast milk. Know all the risks before taking this medication while breastfeeding.

Ampyra (dalfampridine) Form and Strength

Ampyra is available in the following forms and strengths:

• Ampyra, extended-release tablets
  • 10 mg
• Dalfampridine (generic), extended-release tablets
  • 10 mg

FAQ

Does Ampyra help with balance?

Ampyra may help with balance and manual ability in some cases. However, these effects were not statistically significant when studied.

How quickly does Ampyra work?

It takes a couple of weeks for a patient’s walking ability to improve with Ampyra. Significant improvements can be noticed in six weeks.

Does Ampyra suppress the immune system?

Some patients taking Ampyra have reported immunosuppression, therefore it is best to avoid people who have an active infection while taking this medication.

Does Ampyra have kidney side effects?

Ampyra is eliminated through the kidneys, therefore prolonged use of this medication may cause renal impairment and increase the risk of seizures.

Resources

https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/022250s006lbl.pdf

https://www.webmd.com/drugs/2/drug-153649/ampyra-oral/details