Lotrel (Amlodipine/Benazepril) from Maple Leaf Medications.

Lotrel (amlodipine/benazepril) Indications

Lotrel, generic amlodipine/benazepril, is a combination medication used for the treatment of high blood pressure (hypertension), especially for individuals who do not respond to a single medication. Amlodipine is a calcium channel blocker and benazepril is an angiotensin-converting enzyme (ACE) inhibitor. This combination helps prevent strokes, heart attacks, and kidney problems in people with high blood pressure.

Healthcare providers may prescribe Lotrel for other conditions based on their clinical judgment and the individual needs of their patients.

Lotrel (amlodipine/benazepril) Uses and Dosage

Carefully review the prescription guide to ensure that you understand all the details associated with taking Lotrel.

It is important to take Lotrel exactly as prescribed. Do not change the dose or stop taking the medication without consulting with a healthcare provider. The usual starting dose of Lotrel is one capsule by mouth once daily — normal dosage range is 2.5 mg/10 mg-10 mg/40 mg once daily.

Lotrel is taken by mouth with a full glass of water and with or without food. The capsules must be swallowed whole and should not be crushed or chewed since doing so may alter the effectiveness of the medication.

Lotrel (amlodipine/benazepril) Side Effects

Some of the common side effects of Lotrel include:

• Dizziness or lightheadedness
• Headache
• Dry cough
• Swelling in the legs or ankles
• Fatigue
• Nausea and vomiting
• Diarrhea or constipation

Less common but serious side effects may include:

• Irregular heartbeat
• Fainting
• Muscle weakness
• Changes in urine output
• Loss of appetite
• Severe abdominal pain
• Persistent nausea and vomiting
• Jaundice
• Chest pain

Promptly seek medical assistance if you encounter any of these severe side effects.

Some individuals may develop allergic reactions to Lotrel that can be serious and potentially life-threatening. Discontinue Lotrel and seek emergency medical care once symptoms of hypersensitivity develop. These symptoms include:

• Itching
• Hives/rash
• Swelling of tongue, lips, face
• Difficulty breathing

Lotrel (amlodipine/benazepril) Cautions

Individuals who have the following medical conditions should not use Lotrel:

• Aortic stenosis
• History of angioedema
• Severe kidney disease
• Severe liver impairment

Lotrel has the possibility of interacting with several drugs, which can either reduce its effectiveness or heighten the probability of adverse effects. These drugs comprise a range of medications such as:

• Potassium supplements or potassium-sparing diuretics
• Lithium
• Simvastatin or other drugs used to lower cholesterol
• Antidepressants or other medications that affect serotonin levels in the brain
• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Other medications used to lower blood pressure

Avoid driving or operating any heavy machinery while taking Lotrel as it may cause drowsiness, dizziness, or other side effects that can impair your ability to perform tasks that need mental alertness or physical coordination.

Lotrel (amlodipine/benazepril) Form and Strength

Lotrel is available in the following forms and strengths:

• Lotrel capsule
  • 5 mg/10 mg
  • 5 mg/10 mg
  • 5 mg/20 mg
  • 5 mg/40 mg
  • 10 mg/20 mg
  • 10 mg/40 mg
• Amlodipine/Benazepril capsule
  • 5 mg/10 mg
  • 5 mg/10 mg
  • 5 mg/20 mg
  • 5 mg/40 mg
  • 10 mg/20 mg
  • 10 mg/40 mg

FAQ

Does Lotrel contain a diuretic?

Lotrel does not contain a diuretic. This medication is a combination of a calcium channel blocker (amlodipine) and an angiotensin converting enzyme inhibitor (benazepril).

How long does Lotrel stay in your system?

It can be estimated that Lotrel will be completely eliminated from your body within 5-7 days after stopping the medication.

Resources

1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020364s065lbl.pdf
2. https://www.webmd.com/drugs/2/drug-16188/lotrel-oral/details
3. https://www.drugs.com/lotrel.html
4. https://www.rxlist.com/lotrel-drug.htm