Buy Compazine Suppository


Formulation : Suppository
Dosage : 10mg
Quantity : 10
Prescription Prescription Required
(All Prices in USD)

What is Compazine Suppository used for? 

Compazine, with the generic name prochlorperazine, is a prescription suppository prescribed for severe nausea and vomiting caused by surgery or cancer treatment. This is classified as phenothiazine.

This is available in Compazine 10 mg suppository.

How does Compazine Suppository work?

This suppository is being used mainly for its antiemetic effect. It has a depressant action on the chemoreceptor trigger zone and blocks D2 dopamine receptors in the brain. Compazine Suppositories can also block cholinergic, nonadrenergic, and histaminergic receptors.

How to use Compazine Suppository

Do not use this suppository without reading the full medication guide. Ensure you know how to use this product correctly before using it for the first time. You may talk to your physician or any concerned healthcare professional for concerns or queries.

This rectal suppository is usually administered two times a day. Do not change the Compazine suppository dosing. To insert the suppository rectally, lie down on your side. Using your finger, insert the prescription suppository into the rectum. Stay in a lying down position for a few minutes and avoid bowel movement for one hour or longer to allow the medication to be absorbed.

Compazine Suppository Side Effects 

Common side effects: 

  • Dizziness 
  • Lightheadedness 
  • Drowsiness 
  • Blurred vision
  • Dry mouth
  • Constipation 

Most of the adverse effects brought about by this rectal suppository are mild and temporary. If they become worse or if they persist, you should report them directly to your healthcare provider. You must also immediately report any serious unwanted effects, such as: 

  • Menta, mood, or behavior changes 
  • Tremors
  • Uncontrolled movements
  • Enlarged breast or breast tenderness
  • Difficulty urinating
  • Weakness
  • Easy bruising and/or bleeding
  • Fever
  • Persistent sore throat
  • Seizures
  • Neuroleptic malignant syndrome 

Precautions when using Compazine Suppository

This prescription suppository may be contraindicated for those patients with a history of immune system disorders, blood disorders, asthma, COPD, heart disease, brain disorders, liver disorders, kidney disorders, glaucoma, pheochromocytoma, and gastrointestinal disorders. You should also talk to your physician regarding the OTC and prescription medication you are taking due to possible drug interactions.

Do not use this rectal medication if you have a known allergy to prochlorperazine or other phenothiazines. Call for emergency medical management once you encounter signs of severe hypersensitivities, such as itching, swelling of the face, rashes, severe dizziness, wheezing, and trouble breathing.

Using this prescription medication may or may not cause harm to unborn babies. Pregnant moms should use this suppository only if strongly recommended. 

It is undetermined whether this suppository can be excreted into breast milk. Discuss all the possible risks before using this product.

How much does Compazine Suppository cost in Canada?

You may check the price of this rectal suppository from the information above. For the best prices and top-quality products, order from

Frequently Asked Questions

How effective is Compazine Suppository for nausea?

This rectal medication has been proven to be effective for severe and persistent nausea. It could relieve nausea in 30 to 60 minutes.

What should I do if Compazine Suppository is too soft to insert? 

If the suppository is too soft to insert, leave it in the refrigerator. You may try inserting it again after 20 to 30 minutes.

How far do you push a Compazine suppository? 

For adults, this suppository must be inserted 1 inch into the rectum. For children, it should be inserted half an inch.

How long does it take for a Compazine suppository to work? 

This rectal suppository may start to work in as fast as 30 minutes. If it cannot relieve nausea and vomiting in 2 hours, you must call your healthcare provider.

Does Compazine make you sleepy? 

Yes, drowsiness is a very common unwanted effect of using this suppository. In addition, it may also cause dizziness and blurred vision.

Is Compazine and Zofran the same thing? 

Compazine and Zofran may be indicated for the same medical conditions. However, they belong to different drug classes.

Is there a generic for Compazine? 

Prochlorperazine rectal suppository is the generic alternative to this brand-name medication. Consult with your doctor before switching to a generic alternative. 

Brand Name:

Compazine Suppository

Scientific Name:


Other Names:

Prochlorperazine Suppository



Quantities Available:




Maple Leaf Medications has provided information from third parties intended to increase awareness and does not contain all the information about Compazine Suppository (Prochlorperazine). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Compazine Suppository (Prochlorperazine).