Premarin (Conjugated Estrogen) from Maple Leaf Medications.

Prescription Prescription Required
Formulation : Tablet
Drug Name Dosage Quantity Price Buy Now
Premarin 0.625mg 28 $35.00 Add To Cart
Premarin 0.3mg 28 $35.00 Add To Cart
Premarin 0.3mg 56 $55.00 Add To Cart
Premarin 0.3mg 84 $74.00 Add To Cart
Premarin 0.625mg 84 $61.00 Add To Cart
Premarin 0.9mg 100 $710.00 Add To Cart
Premarin 0.45mg 100 $710.00 Add To Cart
Premarin 1.25mg 28 $36.00 Add To Cart
Premarin 1.25mg 84 $78.00 Add To Cart
Dosage: 0.625mg
Quantity: 28
Price: $35.00
Dosage: 0.3mg
Quantity: 28
Price: $35.00
Dosage: 0.3mg
Quantity: 56
Price: $55.00
Dosage: 0.3mg
Quantity: 84
Price: $74.00
Dosage: 0.625mg
Quantity: 84
Price: $61.00
Dosage: 0.9mg
Quantity: 100
Price: $710.00
Dosage: 0.45mg
Quantity: 100
Price: $710.00
Dosage: 1.25mg
Quantity: 28
Price: $36.00
Dosage: 1.25mg
Quantity: 84
Price: $78.00

What is Premarin used for?

Premarin, with the generic name conjugated estrogen, is an oral medication indicated to treat moderate-severe symptoms of vulvar and vaginal atrophy and vasomotor symptoms like hot flashes due to menopause. It is also used to address hypoestrogenism caused by hypogonadism, castration, or primary ovarian failure. Premarin could also help prevent postmenopausal osteoporosis.

This is available in Premarin 0.625 mg, 0.9 mg, 1.25 mg, 0.45 mg, and Premarin 0.3 mg tablet forms.

Mechanism of Action

This estrogen derivative works by increasing the DNA, RNA, and other proteins synthesis in certain tissues. It could also lessen the release of gonadotropin-releasing hormone, follicle-stimulating hormone, and luteinizing hormone. As a result, it promotes normal growth and development of female sex organs. It also maintains genitourinary function and vasomotor stability. In addition, this drug could also inhibit bone resorption.

How to use Premarin

To begin, read the medication information sheet included with this medicine. Do not take this oral medication if you have not fully understood the drug information and instructions printed in the guide. If you have further queries about using this conjugated estrogen or need medical advice, you can ask your physician or pharmacist.

Take this tablet orally. You may take it with or without a meal or as directed by your doctor. If you develop stomach upset upon taking this drug, you must take it with food. Swallow this drug and drink a glass of water thereafter. This drug should not be crushed, chewed, or divided.

Remember to take this drug regularly and with a dosing schedule to achieve the best results. Your Premarin dosage will depend on your medical condition and response to treatment. Do not alter your dose or stop taking this drug abruptly without the advice of your physician, as it could lead to worsening conditions.

Premarin Side Effects

Common side effects:

  • Nausea
  • Headache
  • Dizziness
  • Vomiting
  • Bloating
  • Stomach upset
  • Breast tenderness
  • Tiredness
  • Weight changes

In most cases, the side effects caused by this prescription medication are mild and will resolve after a few days. If the adverse reactions persist or worsen over time, you should call your doctor or any healthcare provider. Moreover, you must report severe side effects, including:

  • Unusual vaginal bleeding
  • Breast lumps
  • Increased vaginal irritation and discharge
  • Mental or mood changes
  • Severe abdominal pain
  • Persistent vomiting
  • Yellowish skin
  • Swelling of the extremities
  • Dark urine
  • Signs of deep vein thrombosis or pulmonary embolism (chest pain, severe headache, unusual sweating, difficulty breathing, sudden dizziness, fainting)

This is not an exhaustive list of Premarin’s negative effects.

Precautions when using Premarin

Before using this oral tablet, you must fully disclose your medical history to your physician, including any history of blood clots, stroke, certain cancers, unusual vaginal bleeding, heart disease, liver problems, kidney disease, hypertension or high blood pressure, diabetes, mineral imbalance, hormone problems, gallbladder problems, uterus problems, asthma, seizure, and mental disorders. Certain conditions may greatly affect how you will respond to this treatment. Additionally, you must talk about all the prescription drugs, nonprescription drugs, and supplements you are taking, for they may have drug interactions with estrogen.

Always be watchful for an allergic reaction while taking this drug. Do not take this tablet if you have a known allergy to its active ingredient or any inactive ingredients it may contain. Signs of hypersensitivity are severe dizziness, red patches on the skin, swelling of the face, hives, and breathing trouble. If this happens, get medical treatment right away.

Avoid using tobacco or smoking while taking conjugated estrogens. They contain a substance that could increase the risk of blood clots, stroke, hypertension, and heart attack, especially in women above the age of 35.

Tell your healthcare provider if you will be confined in a certain position for a long time. This includes undergoing surgery or going on long-haul flights. Limited movement could also increase the risk of blood clots.

This drug may make you more sensitive to the sun and cause blotchy and dark areas on the skin. Limit your sun exposure and avoid indoor tanning to avoid this. You should also wear protective clothing and apply sunblock cream when going outdoors.

Pregnant and breastfeeding moms should avoid Premarin because of the potential dangers it may cause. Always remember that potential risks must outweigh potential benefits.

Frequently Asked Questions

Is this medication safe?

Premarin is proven safe. Even so, you must consult your physician if you encounter severe and unusual adverse effects because this medication could increase the risk of endometrial cancer and uterine cancer.

How long does this medication take to work?

It could take about a month before you notice an improvement in your menopausal symptoms.

When is the best time to take this medication?

Postmenopausal women could take this medication any time of the day provided that it is the same time of the day, each day.

What is the difference between Estrace and Premarin?

On Estrace vs Premarin, the former is estradiol, whereas the latter is conjugated estrogen.

Can I purchase this medication over the counter?

In order to purchase this drug from our website, you must have a valid prescription for Premarin.

Brand Name:


Scientific Name:

Conjugated Estrogen

Other Names:



0.3mg, 0.9mg, 0.45mg, 0.625mg, 1.25mg

Quantities Available:

28, 56, 84, 100



Maple Leaf Medications has provided information from third parties intended to increase awareness and does not contain all the information about Premarin (Conjugated Estrogen). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Premarin (Conjugated Estrogen).

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