Premarin Vaginal Cream (Conjugated Estrogen) from Maple Leaf Medications.

( Top Brand Option )

Price Match See Generic Alternative to (Premarin Vaginal Cream) Pricing Below.

Buy Brand Premarin Vaginal Cream

Prescription Prescription Required
Formulation : Cream
Drug Name Dosage Quantity Price Buy Now
Premarin Vaginal Cream 0.625mg 30grams $55.00 Add To Cart
Premarin Vaginal Cream
Dosage: 0.625mg
Quantity: 30grams
Price: $55.00


What is Premarin? 

Premarin Vaginal Cream, with the generic name conjugated estrogens, is a medication used to treat atrophic vaginitis and kraurosis vulvae. It is also indicated to treat symptoms of menopause, such as severe dyspareunia and vaginal atrophy. This drug is available in Premarin 0.625 mg/g vaginal cream. 

This female hormone regulates the pituitary release of gonadotropins, luteinizing hormones (LH), and follicle-stimulating hormones (FSH) through a negative feedback mechanism. It develops and maintains the female reproductive system and secondary sexual characteristics. 

How to use Premarin Vaginal Cream 

To start, read the medication information leaflet that comes with this cream. Do not use this vaginal medication unless you have fully understood all information in the guide and how it is applied. If you need further medical advice or more questions on this drug, do not hesitate to ask your doctor or pharmacist. 

Use Premarin regularly and exactly as prescribed by your physician for best results. Follow a dosing schedule to avoid missing your Premarin Vaginal Cream dosage. Do not alter your dosage as it would depend on your medical condition and response to treatment. 

Step by step guide in applying Premarin: 

  1. Hold the tube and remove the cap. Then, screw the nozzle of the applicator into the tube. 
  1. Gently squeeze the tube to push the cream into the barrel. There are marked points on the Premarin Vaginal Cream applicator that allows you to measure your prescribed dose. 
  1. Unscrew to remove the applicator from the tube. 
  1. In a comfortable position, gently insert the applicator high into the vaginal opening. Push the plunger fully to deliver medication. 
  1. Once done, remove the applicator slowly. 
  1. Cleanse the applicator by pulling off the plunger and rinsing the applicator with gentle soap and water. 

Side effects 

Common side effects of Premarin 

  • Nausea 
  • Dizziness 
  • Headache 
  • Fatigue 
  • Vomiting 
  • Stomach cramps 
  • Breast tenderness 
  • Bloating 
  • Weight changes 
  • Changes in appetite 
  • Darkening of facial skin 
  • Vaginal itching. 

Most side effects caused by this drug are mild and temporary. However, if you start to experience worsening or persistent adverse effects, seek medical help immediately. You would also have to look out for severe adverse events such as the occurrence of: 

  • Unusual vaginal bleeding 
  • Breast lumps 
  • Increased vaginal irritation 
  • Unusual vaginal discharge 
  • Severe stomach pain 
  • Persistent vomiting, swelling of the extremities 
  • Mental changes 

Note that this is not a full and complete list of Premarin side effects. 


Before using this cream, make sure to disclose full medical history to your physician, especially that of stroke, blood clots, heart disorder, swelling disorder, liver problem, kidney disease, hypertension, diabetes, hyperthyroidism, uterus problems, gallstones, asthma, seizure, migraine, mental disorder, or cancer. These medical conditions may significantly impact how your body would respond to treatment. In addition, tell your doctor about all prescription drugs, nonprescription drugs, herbal medications, and supplements you are taking, as they may interact with conjugated estrogens. 

It is essential to look out for Premarin allergy while using this vaginal cream. Do not use this vaginal drug if you have a known allergy to its active or inactive ingredients. Discontinue medication and alert your local emergency line if you notice signs of hypersensitivity reaction such as severe dizziness, swelling of the face, hives, difficulty breathing, and skin rashes. 

Taking estrogen increases the risk of blood clot formation. To address this, avoid smoking and tobacco. Inform your physician if you will be confined in a particular position for a long time (i.e., long haul flight, surgery). Limited movement would further increase the risk of blood clots. 

This medication can cause dark patches on the skin and face. Minimize sun exposure while on this treatment. Apply sunblock lotion and wear protective clothing when going outdoors. Also, avoid indoor tanning. 

Mineral oil is one of the ingredients of this cream. This substance could weaken rubber products such as condoms, cervical caps, and diaphragms, leading to failure. Consult your healthcare provider about other birth control methods that you could use while on Premarin. 

This vaginal cream is not intended for pregnant and breastfeeding women. 

Frequently Asked Questions 

Is Premarin safe for long-term use? 

Because of its risks, Premarin should be used only when necessary. Follow the length of time prescribed by your physician. 

How often should I use this cream? 

Your dosage and frequency depend on the recommendation of your doctor. 

When is the best time to administer this cream? 

It is best to apply this cream at bedtime for less leakage. 

Does this cream cause weight gain? 

Weight changes (weight loss or weight gain) are among the side effects of this medication. 

How much does Premarin Vaginal Cream cost? 

You may check the pricing of this product by clicking here.

Additional information

Drug Name:

Premarin Vaginal Cream

Scientific Name:

Conjugated Estrogen

Other Names:

Premarin Cream



Quantities Available:




Maple Leaf Medications has provided information from third parties intended to increase awareness and does not contain all the information about Premarin Vaginal Cream (Conjugated Estrogen). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Premarin Vaginal Cream (Conjugated Estrogen).