Premarin Vaginal Cream (Conjugated Estrogen) from Maple Leaf Medications.

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Formulation : Cream
Drug Name Dosage Quantity Price Buy Now
Premarin Vaginal Cream 0.625mg 30grams $55.00 Add To Cart
Premarin Vaginal Cream
Dosage: 0.625mg
Quantity: 30grams
Price: $55.00

Premarin Vaginal Cream (conjugated estrogen) Indications

Premarin Vaginal Cream, generic name conjugated estrogens, is a topical medication used by women after menopause. It is prescribed for the treatment of moderate to severe dyspareunia or painful intercourse due to vulvar and vaginal atrophy.

Premarin Vaginal Cream can also treat atrophic vaginitis and kraurosis vulvae caused by menopause. This cream is designed to help relieve symptoms such as vaginal itching, burning, and dryness.

Premarin Vaginal Cream is classified as an estrogen derivative. Estrogen is responsible for maintaining and developing the female reproductive system, as well as secondary sexual characteristics. It also helps in modulating the pituitary secretion of luteinizing hormones, gonadotropins, and follicle-stimulating hormones.

Premarin Vaginal Cream (conjugated estrogen) Uses and Dosage

You must read the drug guide that comes with Premarin Vaginal Cream.

Make sure to apply Premarin Vaginal Cream exactly as prescribed by the doctor. This medical cream is typically administered two times a week. Make a dosing schedule and apply it on the same days every week.

This prescription cream is applied intravaginally (inside the vagina) using an applicator.

How to apply Premarin Vaginal Cream:

  1. Remove the cap of the tube.
  2. Screw the applicator onto the tube.
  3. Carefully squeeze the tube from the bottom to force the cream into the barrel of the applicator. Use the marked points for measurement.
  4. Unscrew the applicator.
  5. Lie on your back with knees up.
  6. Gently insert the applicator into the vagina. Then, push the plunger to move the medication to the inside of the vagina.
  7. Pull the applicator out once you are done applying the medication.
  8. Clean the applicator using warm water and mild soap.

Premarin Vaginal Cream (conjugated estrogen) Side Effects

Some of the common side effects of Premarin Vaginal Cream are the following:

  • Bloating
  • Headache
  • Nausea
  • Vomiting
  • Dizziness
  • Stomach cramps
  • Changes in appetite
  • Weight changes
  • Breast pain, tenderness, swelling

These adverse effects should be mild and easy to manage. If they get worse, you must consult your doctor.

Serious Side Effects

You may also experience certain adverse reactions that are severe. Here are some of them:

  • Depression, memory loss, or any changes in mood and behavior
  • Increased vaginal irritation
  • Unusual vaginal bleeding
  • Breast lumps
  • Persistent nausea and vomiting
  • Severe abdominal pain
  • Swelling of the ankles and feet
  • Severe headache
  • Confusion
  • Chest pain
  • Unusual sweating
  • Sudden vision changes
  • Tingling sensation or numbness in the arms and legs
  • Trouble breathing
  • Severe dizziness
  • Fainting

These serious side effects should be reported right away.

Allergic Reactions

Do not apply Premarin Vaginal Cream if you have an allergy to estrogen derivatives or any ingredients that this may contain. Seek emergency help if an allergy develops. Here are some of the common signs of an allergy:

  • Itching
  • Rashes
  • Hives
  • Swelling of the face and neck
  • Wheezing
  • Breathing difficulty
  • Persistent dizziness

Premarin Vaginal Cream (conjugated estrogen) Cautions

Premarin Vaginal Cream may be contraindicated for women with:

  • Breast cancer, ovarian cancer, or cancer of the uterus
  • Vaginal bleeding of unknown cause
  • Uterus problems
  • Stroke
  • Breast lumps
  • Porphyria
  • Liver disease
  • Kidney disease
  • Blood clotting disorders
  • Diabetes
  • Obesity
  • Lupus
  • High cholesterol
  • Mineral imbalance
  • Hypothyroidism
  • Hypoparathyroidism
  • Hypertension
  • Seizures
  • Asthma
  • Migraine headaches
  • Gallbladder disease
  • Mental or mood disorders

Avoid using tobacco, e-cigarettes, and smoking while applying Premarin Vaginal Cream. Nicotine can increase the risk of blood clots, stroke, heart attack, and high blood pressure.

Premarin Vaginal Cream is not prescribed for pregnant and breastfeeding women, consult your doctor if you may be pregnant or are breastfeeding.

Premarin Vaginal Cream (conjugated estrogen) Form and Strength

Premarin Vaginal Cream is available in:

  • Premarin Vaginal Cream
    • 625 mg


Can I use Premarin Vaginal Cream every day?

Premarin Vaginal Cream is administered intravaginally in a cyclic regimen. This type of medication is not meant for everyday use.

What happens when you stop using Premarin Vaginal Cream?

Once you stop using this vaginal cream, the symptoms of menopause may return. In some cases, women are also left with a rise in blood pressure and a moderate increase in the risk of stroke or heart attack.

How long before Premarin Vaginal Cream takes effect?

This topical medication for symptoms of menopause may not work right away. It may start to relieve vulvar or vaginal dryness, irritation, and itching after four weeks of use.



Brand Name:

Premarin Vaginal Cream

Scientific Name:

Conjugated Estrogen

Other Names:

Premarin Cream



Quantities Available:




Maple Leaf Medications has provided information from third parties intended to increase awareness and does not contain all the information about Premarin Vaginal Cream (Conjugated Estrogen). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Premarin Vaginal Cream (Conjugated Estrogen).

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