Lanvis (Thioguanine) from Maple Leaf Medications.

Lanvis (thioguanine) Indications

Lanvis, generic name thioguanine, is a chemotherapy drug used to treat types of leukemia, including acute myelogenous leukemia (AML), acute lymphoblastic leukemia (ALL), and chronic granulocytic leukemia.

With these leukemias, abnormal blood cells are made in the bone marrow and multiply rapidly interfering with normal blood cell function. Thioguanine works by inhibiting the growth and multiplication of cancer cells, thereby helping to control the disease.

Thioguanine is frequently administered with other prescription medications in the treatment of hematologic malignancies, specifically leukemias (blood cancers).

Lanvis (thioguanine) Uses and Dosage

Thoroughly review the medication guide as it contains important and detailed information about thioguanine, including its uses, potential adverse effects, precautions, and instructions for safe and effective administration.

The starting dose of thioguanine is 2-3 mg/kg of body weight taken by mouth with water as a single daily dose or divided into multiple doses. Dosage adjustments may be made based on the individual’s response to treatment and any potential side effects.

Avoid breaking the thioguanine tablets unless instructed by a healthcare professional.

The duration of thioguanine treatment is contingent upon the specific blood cancer being treated and individual response to therapy. Adherence to the prescribed treatment plan is important, regardless of if symptomatic improvement is observed.

Lanvis (thioguanine) Side Effects

Some of the common side effects may include:

• Nausea
• Vomiting
• Diarrhea
• Loss of appetite
• Hair loss

Serious side effects associated with thioguanine are relatively rare., yet should they occur seek medical attention. Serious side effects may include:

• Severe anemia
• Increased susceptibility to infection
• Unusual bruising and bleeding
• Yellowing of skin/eyes
• Dark/bloody urine
• Severe abdominal pain
• Persistent nausea and vomiting
• Unusual fatigue
• Tumor lysis syndrome

In addition, thioguanine has the potential to induce allergic reactions, which may manifest as severe skin rash, itching, swelling, breathing difficulties, or dizziness. If you experience any indications of an allergic reaction, promptly seek emergency medical assistance.

Lanvis (thioguanine) Cautions

Individuals with the following conditions/situations should not use thioguanine:

• Severe bone marrow suppression
• Severe liver disease
• Kidney disease
• Lesch-Nyhan syndrome
• Pregnancy
• Breastfeeding

Thioguanine can interact with certain medications and substances, which may include:

• Allopurinol
• Aminosalicylate derivatives (olsalazine, mesalazine, sulphasalazine)
• Live vaccines
• Mercaptopurine
• Other chemotherapy agents

Regular monitoring of blood cell counts (platelets, red blood cells, white blood cells), is essential during thioguanine treatment. Notify your healthcare provider at once if you experience unusual bleeding, bruising, persistent fever, signs of infection, or any other concerning symptoms.

Lanvis (thioguanine) Form and Strength

Lanvis is available in the following form:

• Lanvis tablet
  • 40 mg

FAQ

Is Lanvis immunosuppressive?

Yes, Lanvis can exhibit immunosuppressive effects.

How long do you take Lanvis?

The duration of Lanvis treatment can range from several weeks to months or longer.

Resources

1. https://www.medsafe.govt.nz/consumers/cmi/l/lanvis.pdf
2. https://www.medbroadcast.com/drug/getdrug/lanvis#adverseeffects
3. https://www.healthdirect.gov.au/medicines/brand/amt,4436011000036106/lanvis