Vivelle DOT (Estradiol Hemihydrate) from Maple Leaf Medications.

Prescription Prescription Required
Formulation : Transdermal Patches
Drug Name Dosage Quantity Price Buy Now
Vivelle DOT 25mcg 16 $75.00 Add To Cart
Vivelle DOT 25mcg 24 $110.00 Add To Cart
Vivelle DOT 50mcg 8 $54.00 Add To Cart
Vivelle DOT 50mcg 24 $134.00 Add To Cart
Vivelle DOT 75mcg 24 $107.00 Add To Cart
Vivelle DOT 100mcg 8 $50.00 Add To Cart
Vivelle DOT 100mcg 24 $123.00 Add To Cart
Vivelle DOT 37.5mcg 8 $45.00 Add To Cart
Vivelle DOT 37.5mcg 24 $107.00 Add To Cart
Vivelle DOT
Dosage: 25mcg
Quantity: 16
Price: $75.00
Vivelle DOT
Dosage: 25mcg
Quantity: 24
Price: $110.00
Vivelle DOT
Dosage: 50mcg
Quantity: 8
Price: $54.00
Vivelle DOT
Dosage: 50mcg
Quantity: 24
Price: $134.00
Vivelle DOT
Dosage: 75mcg
Quantity: 24
Price: $107.00
Vivelle DOT
Dosage: 100mcg
Quantity: 8
Price: $50.00
Vivelle DOT
Dosage: 100mcg
Quantity: 24
Price: $123.00
Vivelle DOT
Dosage: 37.5mcg
Quantity: 8
Price: $45.00
Vivelle DOT
Dosage: 37.5mcg
Quantity: 24
Price: $107.00

Vivelle DOT Uses 

Vivelle DOT, with the generic name estradiol, is a transdermal system indicated to treat moderate-severe vasomotor symptoms and vulvar & vaginal atrophy due to menopause. It is also used to treat hypoestrogenism secondary to hypogonadism, primary ovarian failure, or castration. It also prevents postmenopausal osteoporosis. 

This is available in Vivelle DOT 0.1 mg/day, 0.075 mg/day, 0.05 mg/day, 0.0375 mg/day, and 0.025 mg/day transdermal system. 

Vivelle DOT Mechanism of Action 

This estrogen works by reducing the release of luteinizing hormone and gonadotropin-releasing hormone from the hypothalamus and gonadotropin release from the pituitary glands. It also acts by increasing the synthesis of DNA, RNA, and certain proteins in the target tissues. This is because this hormone is mainly responsible for the maintenance and development of the female reproductive system and secondary sexual characteristics. 

How to use Vivelle DOT 

To begin, read the Vivelle Dot guide or information leaflet that comes with this product. Avoid using this medication unless you have fully understood the drug information and precautions in the guide provided. If you have further inquiries on how to administer this patch or need more medical advice, you can ask your doctor or pharmacist. 

This patch should be applied to the lower abdomen, just below the waistline. Do not apply a new patch to the same area for at least a week. Make sure the application site is clean and free from oil, powder, or lotion. Tear the pouch open and peel off the backing of the patch. Apply the sticky side to your selected area. Keep your fingers away from the sticky side. Then, press the patch firmly for about 10 seconds to ensure that it will stay in place. 

Remember to use this patch regularly and exactly as directed. Do not alter your Vivelle DOT dosage or length of treatment as it is based on your medical condition and response to therapy. Also, do not stop using this transdermal patch without the advice of your physician, as it could lead to rebound effects. 

Vivelle DOT Side Effects 

Common side effects: 

-Redness or irritation on the application site 




-Stomach upset 


-Weight changes 



-Breast tenderness 

Mostly, the side effects caused by this prescription medication are mild and temporary. If the adverse reactions worsen or persist, you should golf the drug and consult your doctor or any healthcare professional. It is also important to report severe side effects, including: 

-Mental or mood changes, including memory loss or depression 

-Unusual vaginal bleeding 

-Breast lumps 

-Severe abdominal pain 

-Increased vaginal irritation 

-Persistent vomiting 

-Dark urine 

-Swelling of the extremities 

-Increased thirst or urination 

-Symptoms of blood clots (chest pain, severe headache, unusual sweating, confusion, weakness on one side of the body, trouble speaking, coughing out blood) 


-Trouble breathing 

This is not a complete or full list of the side effects of Vivelle DOT. 

Precautions when using Vivelle DOT 

Before you begin using this patch, you should disclose your entire medical history to your physician. This includes any history of blood clotting disorders, angioedema, diabetes, high blood pressure, high cholesterol or triglyceride levels, hypothyroidism, mineral imbalance, lupus, obesity, liver disease, kidney disease, breast cancer, uterus cancer, ovarian cancer, vaginal bleeding of unknown cause, hypoparathyroidism, gallbladder disease, porphyria, seizures, asthma, dementia, or depression. Some diseases or disorders may impact how your body will respond to the treatment. Moreover, you should discuss all prescription drugs, nonprescription drugs, supplements, and herbal products you are taking because of possible drug interactions with estrogen. 

During this treatment, be aware of an allergic reaction. Do not use this transdermal patch if you have a known allergy to estradiol or any inactive ingredients it may contain. Signs of hypersensitivity are breathing difficulty, swelling, itchiness or hives, skin rashes, and severe dizziness. If this occurs, discontinue medication and alert your local medical emergency line. 

Avoid smoking or using tobacco while on this medication. Estrogens, if combined with smoking, may increase the risk of blood clots, stroke, heart attack, and hypertension. The risk is higher in women above the age of 35. 

If you will be undergoing an MRI test, make sure to inform the healthcare professional that you have a transdermal patch on. This patch may contain mental that could cause burning during an MRI. Your physician may ask you to remove your patch before a procedure and apply a new one after. 

This medication may cause dark, blotchy patches on the skin, particularly the face. Sun exposure may worsen this adverse effect. As much as possible, limit your sun exposure and avoid indoor tanning. Wearing protective clothing and applying sunblock cream is also essential when going outside. 

Frequently Asked Questions 

Is Vivelle DOT prescribed for vulvar and vaginal atrophy alone? 

This medication is preferred if vasomotor symptoms and vulvar and vaginal atrophy are present. 

What should I do if my Vivelle DOT patch falls off? 

If the patch falls off, apply it to another site. If it does not stick well, apply it to another area and replace the patch as scheduled. 

How can I avoid the adverse effects of this medication? 

You may ask your healthcare provider if you have questions about avoiding or stopping Vivelle DOT side effects. 

Does this transdermal patch cause weight gain? 

Yes, there is a link between Vivelle DOT & weight gain. 

How much does Vivelle DOT cost? 

You may check the pricing of this product by clicking here.


Brand Name:

Vivelle DOT

Scientific Name:

Estradiol Hemihydrate

Other Names:



25mcg, 37.5mcg, 50mcg, 75mcg, 100mcg

Quantities Available:

8, 16, 24


Transdermal Patches

Maple Leaf Medications has provided information from third parties intended to increase awareness and does not contain all the information about Vivelle DOT (Estradiol Hemihydrate). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Vivelle DOT (Estradiol Hemihydrate).