Divigel (Estradiol Gel) from Maple Leaf Medications.

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Formulation : Gel Sachet
Drug Name Dosage Quantity Price Buy Now
Divigel 0.5mg 30 sachets $47.00 Add To Cart
Divigel 0.25mg 30 sachets $47.00 Add To Cart
Divigel 0.5mg 90 sachets $107.00 Add To Cart
Divigel 0.25mg 90 sachets $113.00 Add To Cart
Divigel 1mg 30 sachets $47.00 Add To Cart
Divigel 1mg 90 sachets $106.60 Add To Cart
Dosage: 0.5mg
Quantity: 30 sachets
Price: $47.00
Dosage: 0.25mg
Quantity: 30 sachets
Price: $47.00
Dosage: 0.5mg
Quantity: 90 sachets
Price: $107.00
Dosage: 0.25mg
Quantity: 90 sachets
Price: $113.00
Dosage: 1mg
Quantity: 30 sachets
Price: $47.00
Dosage: 1mg
Quantity: 90 sachets
Price: $106.60

What is Divigel? 

Divigel, with the generic name estradiol, is a topical gel indicated to treat moderate to severe vasomotor symptoms of menopause, like hot flashes, night sweats, and flushes. This occurs due to the constriction or dilation of blood vessels brought about by the fall of estrogen and progesterone levels. 

This is available in Divigel 1.0, 0.5, and 0.25 gram-filled single-dose foil packets. 

How does Divigel work? 

This estradiol gel is absorbed by the skin and goes into the bloodstream. This medication acts by reducing the elevated follicle-stimulating hormone (FSH), luteinizing hormone (LH), and gonadotropins through a negative feedback mechanism. It also helps in developing and maintaining the female reproductive system and secondary sexual characteristics.  

How to use 

To begin, read the attached Divigel leaflet that comes with this product. Avoid using any topical medications if you have not yet fully understood the drug information and instructions written in the guide given to you. If you need further medical advice or have some queries on how this topical drug works, you can ask your doctor or pharmacist. 

You should apply this medication to a clean and dry area of the upper thigh. This is usually prescribed once daily. Alternately apply it on your right and left thigh on each application. Do not apply the gel on broken or irritated skin and other areas like the breast, face, or vagina. Wait for a few minutes until the gel is completely dried. Then, cover the application site with your clothes. Since this medication could be absorbed through the skin, always wash your hands immediately after application to avoid accidentally applying it to other people.  

Remember to use this medication regularly and exactly as directed. Make a dosing schedule to avoid missing your Divigel doses. Do not alter your dosing or frequency as it is based on your medical condition and response to treatment. Also, you should not stop taking this medication abruptly unless advised by your doctor. 

Divigel Side Effects 

Common side effects: 






-loss of appetite 

-swollen breast 

-acne or skin discoloration 

-weight changes 

Mostly, the side effects caused by this medication are mild and short-term. If the adverse reactions aggravate or do not resolve after a while, you must hold this medication and call your doctor or any healthcare professional. Additionally, you must report severe side effects, including: 

-increased vaginal irritation 

-unusual vaginal bleeding 

-breast lumps 

-severe abdominal pain 

-persistent nausea and vomiting 

-dark urine 

-mental or mood changes 

-signs of blood clots (chest pain, trouble breathing, coughing out blood, slurred speech, sudden dizziness, severe headache, vision changes, confusion) 

This is not a full or complete list of the side effects of Divigel. 

Precautions when using Divigel 

Before you begin using this topical drug, you must disclose your complete medical history to your physician, including any history of blood clots, stroke, heart attack, certain cancers, vaginal bleeding of unknown causes, uterus problems, gallbladder disease, angioedema, hypothyroidism, hypoparathyroidism, mineral imbalance, liver disease, seizures, migraine, porphyria, or mental and mood disorders. Some conditions may affect how your system will respond to the treatment. Moreover, you should talk about all the prescription drugs and nonprescription drugs you are taking because of the possible drug interactions with estradiol. 

Be watchful for an allergic reaction while using this gel. Avoid using this topical agent if you have a known allergy to estradiol or any inactive ingredients the gel may contain. Discontinue medication and immediately seek emergency help once you experience signs of hypersensitivity response which includes skin rashes, itchiness, swelling of the face and neck, severe dizziness, and trouble breathing. 

Avoid smoking, using tobacco, or any similar substances that may contain nicotine. This certain substance could increase the risk of high blood pressure, blood clots, heart attack, and stroke, especially among women 35 years of age and older. 

Consult your healthcare provider if you will be confined in a certain position for an extended period of time. This includes going on long-haul flights or going through surgery. This is because limited movements could also increase the risk of blood clot formation. 

This medication may cause dark and blotchy patches on the face or skin called melasma. This skin condition could be worsened by sun exposure. Limit your time under the sun and avoid indoor tanning. You should also apply sunblock cream and wear protective clothing when going outdoors. 

Frequently Asked Questions 

Can I use this medication for anxiety? 

The link between Divigel and anxiety is based on the mental changes that may be caused by this medication. 

Does Divigel help with weight loss? 

This medication could cause weight changes. 

What is the difference between Divigel & Estrogel? 

On Divigel vs Estrogel, the former addresses vasomotor symptoms while the latter could treat both vasomotor and vaginal symptoms. 

Can this medication cause hair loss? 

Yes, there is a direct link between Divigel and hair loss as an adverse effect. 

Is there a direct link between Divigel and weight gain? 

Yes, this topical gel may cause weight changes. 

Brand Name:


Scientific Name:

Estradiol Gel

Other Names:



0.5mg, 0.25mg, 1mg

Quantities Available:

30 sachets, 90 sachets


Gel Sachet

Maple Leaf Medications has provided information from third parties intended to increase awareness and does not contain all the information about Divigel (Estradiol Gel). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Divigel (Estradiol Gel).