Premarin (Conjugated Estrogen) from Maple Leaf Medications.

Premarin (conjugated estrogen) Indications

Premarin, generic name conjugated estrogen, is an oral medication used to treat vasomotor symptoms caused by menopause, such as hot flashes. It also helps relieve the vulvar and vaginal symptoms of menopause, including vaginal dryness, itching, or burning.

Premarin is also used for the prevention of postmenopausal osteoporosis among women who are at risk of developing bone loss; treatment of hypoestrogenism linked to castration, primary ovarian failure, and hypogonadism; for the palliative treatment of breast cancer; and for the treatment of advanced androgen-dependent carcinoma of the prostate.

Premarin is classified as an estrogen derivative. Estrogen is responsible for maintaining and developing the female reproductive system, as well as secondary sexual characteristics. Estrogen also helps regulate the pituitary secretion of luteinizing hormones, gonadotropins, and follicle-stimulating hormones.

Premarin (conjugated estrogen) Uses and Dosage

Before using Premarin, read the patient information guide.

Use Premarin only as prescribed. Premarin is taken by mouth with food and water once daily. Avoid missing a dose. Do not break, divide, chew, or crush this product.

Premarin (conjugated estrogen) Side Effects

Common side effects of Premarin include:

• Stomach upset
• Nausea
• Vomiting
• Bloating
• Headache
• Dizziness
• Tiredness
• Weight changes
• Breast tenderness
• Appetite changes
• Increased hair growth

While these side effects are mostly mild when they occur, consult your doctor if any of these worsen or become unmanageable.

Serious Side Effects

Some of the severe side effects of Premarin include:

• New or increased vaginal irritation
• Unusual vaginal discharge or bleeding
• Breast lumps
• Severe abdominal pain
• Persistent nausea and vomiting
• Sudden vision changes
• Trouble speaking, confusion
• Chest pain
• Shortness of breath
• Sudden dizziness, fainting
• Tingling, weakness, or numbness in arms or legs
• Severe headache
• Coughing up blood

These adverse reactions must be reported to your healthcare provider immediately.

Allergic Reactions

Avoid using Premarin if you have a known allergy to estrogen derivatives. Seek emergency intervention if an allergy develops while using this prescription medication. Signs of an allergy include:

• Trouble breathing
• Wheezing
• Swelling of the face and neck
• Itching
• Severe dizziness
• Hives
• Rashes
• Swollen lymph nodes

Premarin (conjugated estrogen) Cautions

Premarin may be contraindicated for people with any of the following medical conditions:

• Blood clots, stroke, or any cardiovascular disease
• Certain cancers, such as breast, uterine, and ovarian
• Uterus problems
• Vaginal bleeding due to an unknown cause
• Breast lumps
• Diabetes
• High blood pressure
• Obesity
• Lupus
• Angioedema
• Porphyria
• High cholesterol
• Gallbladder disease
• Migraine
• Depression or any mood or mental disorders

Refrain from smoking, using e-cigarettes, and using any tobacco product. These activities can further increase the risk of developing blood clots or having a stroke, heart attack, and high blood pressure.

Premarin should not be used during pregnancy and lactation. Tell your doctor immediately if you become pregnant while using Premarin.

Premarin (conjugated estrogen) Form and Strength

Premarin prescription medication is available as:

• Premarin, tablets
  • 3 mg
  • 45 mg
  • 625 mg
  • 9 mg
  • 25 mg

FAQ

What does Premarin do to your body?

Premarin replaces the estrogen that the body naturally loses during menopause. By replacing estrogen, it can help relieve various symptoms of menopause.

Do you gain weight with Premarin?

Yes, taking medications with estrogen may cause weight gain. You can avoid this by committing to regular exercises and eating healthy meals.

How long should you stay in Premarin?

If Premarin is taken for menopause, then it is usually prescribed long term. On average, menopausal women use this medication for two to three years.

What happens when you stop taking Premarin?

Once women discontinue taking conjugated estrogen tablets, estrogen withdrawal may occur. This can cause hot flashes and night sweats.

Resources

https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/004782s162s164s167lbl.pdf

https://www.premarin.com/about-premarin

https://www.webmd.com/drugs/2/drug-76336/premarin-oral/details

https://www.rxlist.com/premarin-side-effects-drug-center.htm

https://www.drugs.com/premarin.html#dosage