Prempro (Medroxyprogesterone/Estrogen) from Maple Leaf Medications.

This medication is discontinued and cannot be supplied by MapleLeafMeds

What is Prempro Low Dose used for?

Prempro Low Dose, with the generic name conjugated estrogens and medroxyprogesterone acetate, is an oral prescription medication used for the treatment of vasomotor, vulvar, and vaginal symptoms of menopause among women. It helps alleviate dryness in and around the vagina and hot flashes.

It is also used to prevent postmenopausal osteoporosis (bone thinning).

This is available in Prempro Low Dose 5/0.625mg and 1.5/0.3mg tablets.

How does Prempro Low Dose work?

Prempro Low Dose is a combination of two active ingredients. Conjugated estrogens work on maintaining and developing the female reproductive system and secondary sex characteristics. Medroxyprogesterone acetate inhibits the production of gonadotropin, which leads to the prevention of ovulation and cellular maturation.

How to use Prempro Low Dose

Prior to using any oral medication, you must read the prescription leaflet or guide that it comes with. This will help you understand how the medication works and how to use it properly.

You may ask your physician or pharmacist for questions or concerns about this combination drug.

Prempro Low Dose is usually administered once daily, with or without food, or as directed by your doctor. If you experience gastrointestinal symptoms, you may have to take it with food. Take the oral tablet with a dosing schedule. Do not change the prescribed Prempro Low Dose dosage.

Prempro Low Dose Side Effects 

Common side effects: 

  • Breast tenderness 
  • Bloating 
  • Stomach upset
  • Nausea
  • Vomiting
  • Headache
  • Weight changes 

Most of the undesirable effects caused by this prescription drug are temporary and mild. If they exacerbate or if they do not resolve spontaneously, you should report it to your doctor. You must also report serious adverse reactions, such as: 

  • Depression 
  • Memory loss 
  • Breast lumps 
  • Persistent vomiting 
  • Severe nausea
  • Unusual vaginal bleeding
  • Increased vaginal irritation
  • Severe abdominal pain
  • Swelling of the hands and feet
  • Increased thirst
  • Increased urination
  • Chest pain
  • Unusual tiredness
  • Unusual sweating
  • Severe headache
  • Trouble speaking
  • Numbness
  • Sudden dizziness
  • Trouble breathing 

Precautions When Using Prempro Low Dose

Taking this oral prescription drug may be contraindicated for menopausal women with a history of certain cancers, unknown vaginal bleeding, blood clotting disorders, angioedema, high levels of cholesterol, hypertension, diabetes, mineral imbalance, hypothyroidism, porphyria, hypoparathyroidism, and mental disorders. Those using this medication are also advised to take caution when taking other medications because of possible drug interactions.

Do not take this oral tablet if you have had any experience of having an allergic reaction to conjugated estrogen and medroxyprogesterone acetate. Signs of an allergy are wheezing, trouble breathing, severe dizziness, swelling of the face, and itchiness with or without hives. Call for emergency medical assistance once severe hypersensitivity occurs.

Note that this type of medication can cause blood clots, stroke, heart attack, and high blood pressure. Avoid using tobacco or smoking as these may further increase the risk of developing cardiovascular diseases.

This oral drug should not be used during pregnancy and lactation.

How much does Prempro Low Dose cost in Canada?

You may check the price list of this medication from the information reflected above. 

For authentic prescription and over-the-counter drugs, you may order from You may order products through this website. You may call us or fax us.

Frequently Asked Questions

Is Prempro Low Dose a hormone replacement? 

This oral prescription contains conjugated estrogens as one of its active ingredients. It replaces the estrogens lost during menopause.

How quickly does Prempro Low Dose work? 

This product may not work as soon as it has been administered. It may take about three days before menopausal symptoms begin to subside.

What is the best time to take Prempro Low Dose? 

You may take this oral tablet at any time, provided that you will administer it at the same time every day. Take it at a time you will most likely remember, like after breakfast.

What happens when I stop taking Prempro Low Dose? 

Discontinuation of this prescription drug could lead to some unwanted effects. These include the return of vasomotor symptoms, fatigue, bloating, and trouble sleeping.

Will I gain weight on Prempro Low Dose? 

Weight change is a very common adverse reaction to this tablet. Modest weight gain is usually not a cause of concern. However, sudden and unusual weight gain must be reported.

Is it okay to drink alcohol while taking Prempro Low Dose? 

It is best to avoid alcoholic beverages while on this treatment. Alcohol can further increase the levels of estrogen in the system, which also increases the risk of cardiovascular diseases.

Can Prempro Low Dose be cut in half? 

It is best to avoid cutting or splitting this medication. Since this drug is a combination of estrogen and medroxyprogesterone, cutting the drugs can affect the precision of the dosage being administered. 


Brand Name:


Scientific Name:


Other Names:

Premia 2.5 Continuous, Premplus


2.5/0.625mg, noDose

Quantities Available:

1, 28days



Maple Leaf Medications has provided information from third parties intended to increase awareness and does not contain all the information about Prempro (Medroxyprogesterone/Estrogen). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Prempro (Medroxyprogesterone/Estrogen).

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