Cortenema (Hydrocortisone Enema) from Maple Leaf Medications.

Prescription Prescription Required
Formulation : Enema
Drug Name Dosage Quantity Price Buy Now
Cortenema 100mg 420mL $75.00 Add To Cart
Dosage: 100mg
Quantity: 420mL
Price: $75.00

What is Cortenema used for?

Cortenema is a retention enema prescribed for treating ulcerative colitis, especially in distal forms, such as left-sided ulcerative colitis, ulcerative proctitis, and ulcerative proctosigmoiditis. This medication is usually used as an adjunct to other treatments. This is classified as a gastrointestinal corticosteroid.

This is available in Cortenema 100mg in a 420 mL enema.

How does Cortenema work?

This enema’s active ingredient, hydrocortisone, is absorbed in the colon. It has both local and systemic anti-inflammatory effects. It helps decrease the swelling in the colon and rectum, which leads to a decrease in symptoms like bloody stool and diarrhea.

How to use Cortenema

Before you use this retention enema, it is important to know how it works and how it is used. Read the medication guide/patient information leaflet and discuss the use of this medication with your healthcare provider.

This medication is administered through the rectum once daily, preferably at bedtime. Do not change the Cortenema dosage prescribed to you. To apply the medication, assume a side-lying or a knee-chest position. Lubricate the applicator tip of the product. Then, insert the tip gently into the rectum. While holding the bottle firmly, tilt it slightly towards the back and squeeze it slowly to instill the enema. Once the bottle is empty, withdraw the applicator tip and dispose of the bottle properly. Stay in the same position for about 30 minutes.

Cortenema Side Effects

Common side effects: 

  • Mild pain or burning in the rectum 
  • Discomfort 
  • Increased sweating 
  • Dizziness
  • Trouble sleeping
  • Unusual weight gain
  • Unusual hair growth
  • Acne
  • Menstrual changes

The adverse effects caused by this retention enema are usually mild. If they become worse or if they persist, you should report them to your healthcare provider. In addition, you must also report serious adverse reactions, such as: 

  • Persistent rectal bleeding 
  • Persistent headache 
  • Increased thirst 
  • Increased urination
  • Swelling of the lower extremities
  • Puffy face
  • Vision problems
  • Slow wound healing
  • Unusual bleeding
  • Easy bruising
  • Skin thinning
  • Unusual skin growths
  • Muscle weakness
  • Irregular heartbeat
  • Severe heartburn
  • Seizures
  • Painful urination
  • Bone pain

Precautions when using Cortenema

Using this type of product can be contraindicated for people with certain gastrointestinal conditions, certain conditions, certain infections, heart problems, high blood pressure, thyroid problems, diabetes, liver problems, kidney disease, blood clotting problems, myasthenia gravis, mineral imbalances, and some mental conditions. Further, you should talk to your physician regarding all the drugs you are using as they may interact with this retention enema.

Avoid this product if you previously had an allergic reaction to hydrocortisone, other corticosteroids, or other ingredients this solution may contain. Signs of hypersensitivity are usually severe itching, severe dizziness, hives, trouble breathing, and swelling of the face. Emergency help is usually necessary when this occurs.

Using some forms of hydrocortisone can cause harm to unborn babies. Using this enema, especially prolonged use, is not recommended during pregnancy. For nursing mothers, it is unknown if this medication can be excreted into breast milk. Discuss with your physician prior to using this type of medication.

How much does Cortenema cost in Canada?

You may check the Cortenema price from the information above. Please note that a prescription is required each time you purchase this medication. 

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Frequently Asked Questions

How long does Cortenema take to work? 

You may notice certain improvements in your symptoms within three to five days of using this enema. It could take a few weeks to a few months before ulcerative colitis could be in remission.

How long should you leave Cortenema in? 

You must leave your retention enema only for as long as you can hold it. If your urge to evacuate is strong, you may expel the enema.

How long can I use Cortenema? 

You may use this type of medication for up to three to six months. Prolonged use of enemas can lead to systemic side effects.

Can I use Cortenema for hemorrhoids? 

Hydrocortisone can help with the swelling of the anal area. Other alternatives would be in the form of foam or topical ointment.

Are there other alternatives to Cortenema? 

Currently, there are no exact alternatives to Cortenema (generic name: hydrocortisone). However, other forms of treatment can be used for ulcerative colitis.

How much Cortenema is absorbed? 

To some extent, this hydrocortisone enema can be absorbed by the body. According to clinical studies, about 40% of the solution can be absorbed. 


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Maple Leaf Medications has provided information from third parties intended to increase awareness and does not contain all the information about Cortenema (Hydrocortisone Enema). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Cortenema (Hydrocortisone Enema).