Combipatch (Estradiol 17b/Norethindrone Acetate) from Maple Leaf Medications.

What is Combipatch?

Combipatch, with the generic name estradiol-norethindrone acetate, is a transdermal system indicated to treat moderate to severe vasomotor symptoms associated with menopause. It is also used for the symptomatic relief of vulvar and vaginal atrophy linked with menopause. It also treats hypoestrogenism because of hypogonadism, castration, and primary ovarian failure.

This is available in CombiPatch 0.05/0.14 mg and 0.05/0.25 mg dosage forms.

How does Combipatch work?

This drug is a combination of estrogen and progestin-HRT. Primarily, estrogen is responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. It also modulates the pituitary secretion of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and gonadotropins through a negative feedback mechanism. Thus, the elevated levels of these hormones will reduce in postmenopausal women.

How to use Combipatch

To begin, read the medication information sheet included with this medicine. Never use this type of medication if you have not fully understood the instructions and drug information in the guide provided. If you need more medical advice regarding Combipatch or have further inquiries on how this patch is used, you may ask your doctor or pharmacist.

This patch should be applied to the lower abdomen area. Clean & dry the area where the patch will be administered. Note that your patch should be applied in different areas of the lower abdomen for at least one week. To use, get your patch from the Combipatch storage and peel off the backing of the patch. Press it into the intended area firmly for at least ten seconds to ensure that it will stay in place. Do not apply the prescription patch on the breast, areas of the skin where it could be easily removed, like the waistline, and areas that are oily, broken, or irritated. Also, do not expose the patch on the sun for long periods.

Remember to use this drug precisely as prescribed. Make a dosing schedule to avoid forgetting to apply your patch. Do not alter your Combipatch dosage as it is based on your medical condition and response to treatment. Do not alter your dosing or wear two patches at the same time to avoid worsening conditions.

Combipatch Side Effects

Common side effects:

  • Nausea
  • Headache
  • Weakness
  • Vomiting
  • Redness or irritation on the application site
  • Abdominal pain
  • Breast tenderness
  • Back pain
  • Weight changes
  • Dark patches on the face

In most cases, the side effects brought about by this treatment are mild and temporary. If the adverse reactions get worse or do not resolve, you may have to hold the medication for a while and consult your doctor or healthcare professional. Also, you should report severe side effects, including:

  • Mental or mood changes
  • Breast lumps
  • Unusual vaginal bleeding
  • Increased vaginal irritation
  • Unusual vaginal odor or discharge
  • Swelling of the extremities
  • Increased thirst or urination
  • Blood clots

This is not a full or complete list of the side effects of CombiPatch.

Precautions when using Combipatch

Before starting to take this drug, you may have to disclose your complete medical history with your physician, including any history of stroke, blood clots, unusual bleeding of unknown cause, certain cancers (uterine cancer, breast cancer), kidney disease, liver problems, angioedema, blood clotting disorders, high blood pressure, diabetes, high cholesterol, and triglyceride levels, mineral imbalance, hypothyroidism, uterus problems, gallbladder disease, asthma, seizure, migraine, any mental or mood disorders. Some conditions may impact how your body will respond to the drug. Moreover, you should talk about all the prescription drugs, nonprescription drugs, supplements, and herbal products you are taking because of possible drug interactions.

While on this therapy, keep an eye out for any allergic reactions. Do not use this transdermal patch if you have a known allergy to estradiol, norethindrone, or any inactive ingredients each patch may contain. Immediately discontinue the patch and seek emergency medical attention once you notice signs of hypersensitivity, such as severe dizziness, skin rashes, itchiness, swelling of the face and neck, and trouble breathing.

Do not smoke and/or use tobacco while using this transdermal patch. This is because tobacco contains certain ingredients that could further increase the risk of hypertension, stroke, heart attack, and blood clots, especially for those over the age of 35.

Talk to your healthcare provider if you will be confined in a certain position for a long period of time. This includes going on long-haul flights or getting surgery. Limited movements may also increase the risk of blood clots.

This patch may cause dark, blotchy areas on the face and skin. It could be worsened by sun exposure. To reduce the risk, you should limit your sun exposure and avoid indoor tanning. You should also apply sunblock cream when going out.

Frequently Asked Questions

Can I cut Combipatch in half?

You must not cut or split this patch in half.

Does Combipatch cause weight gain?

This prescription medication may cause weight gain.

What should I do if the skin patch falls off?

If the patch falls off, reapply it in the area. If it doesn’t stick, apply a new patch.

How should I dispose my patch?

After removing your patch, fold it with the sticky side together and throw it accordingly. Do not flush it in the toilet.

How much does Combipatch cost?

You may check for the Combipatch price from this page.

Brand Name:


Scientific Name:

Estradiol 17b/Norethindrone Acetate

Other Names:

Estalis Continuous


0.05/0.14mg, 0.05/0.25mg

Quantities Available:

8, 24



Maple Leaf Medications has provided information from third parties intended to increase awareness and does not contain all the information about Combipatch (Estradiol 17b/Norethindrone Acetate). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Combipatch (Estradiol 17b/Norethindrone Acetate).