Combigan (Brimonidine Tartrate/Timolol Maleate) from Maple Leaf Medications.

Prescription Prescription Required
Formulation : Eye Drops
Drug Name Dosage Quantity Price Buy Now
Combigan 0.2/0.5% 5mL $36.00 Add To Cart
Combigan 0.2/0.5% 10mL $56.00 Add To Cart
Combigan 0.2/0.5% 15mL $76.00 Add To Cart
Dosage: 0.2/0.5%
Quantity: 5mL
Price: $36.00
Dosage: 0.2/0.5%
Quantity: 10mL
Price: $56.00
Dosage: 0.2/0.5%
Quantity: 15mL
Price: $76.00

( Affordable Generic Alternatives )

Buy Brimonidine Tartrate/Timolol Maleate Brimonidine Tartrate/Timolol Maleate

Prescription Prescription Required
Formulation : Eye Drops
Drug Name Dosage Quantity Price Buy Now
Brimonidine Tartrate/Timolol Maleate 0.2/0.5% 5mL $32.00 Add To Cart
Brimonidine Tartrate/Timolol Maleate
Dosage: 0.2/0.5%
Quantity: 5mL
Price: $32.00

What is Combigan? 

Combigan, with the generic name brimonidine tartrate and timolol maleate, is an ophthalmic solution used to reduce elevated intraocular pressure or IOP among patients with glaucoma or ocular hypertension. This medication is usually an adjunct to other eye medications when one medication cannot control the IOP. This could also help prevent complications like blindness. 

These eye drops are a combination of alpha-adrenergic receptor agonists and beta-adrenergic receptor inhibitors. This medication has a rapid onset of action and could reach its optimum ocular hypotensive effects within two hours after it has been administered. This is available 2mg/5mg per mL. Combigan bottle sizes are 5mL and 10mL. 

How to use Combigan 

To start, read the medication information leaflet that comes with this medication. Do not use this ophthalmic solution unless you have fully understood the instructions and information in the guide. If you need further medical advice or details on what is Combigan used for, ask your doctor or pharmacist. 

Use this medication regularly and with a dosing schedule to achieve full benefits. Carefully follow the instructions and Combigan eye drops dosage recommended by your doctor. If you are prescribed other eye medications, make sure that there is a 15-minute interval. Note that eye drops should be administered before eye ointments to allow proper drug absorption. 

Contact lenses may absorb some Combigan ingredients. If you have a pair of contact lenses on, remove them before using this medication. You may put it back 15 minutes after using this medication. 

Step by step guide: 

  1. To prevent infection and contamination, wash and dry your hands thoroughly. 
  1. In a comfortable position, slightly tilt your head backward. Pull your lower eyelid, and then look up. 
  1. Place the tip of the dropper right above your eye and press the bottle to dispense a drop. Make sure that the tip of the dropper will not touch your eye. 
  1. Gradually, look down and close your eye. Keep it closed for at least two minutes. Also, press the inner corners of the eye to prevent the solution from draining. Do not squint or blink. 

Side effects 

Common side effects of Combigan: 

  • Temporary blurred vision 
  • Temporary eye discomfort 
  • Temporary redness of the eye 
  • Watery eyes 
  • Puffy eyes 
  • Dry mouth 
  • Headache 
  • Dizziness 
  • Drowsiness 

In most cases, the adverse effects of this drug are mild and temporary. If they get worse or do not disappear over time, call your doctor or any healthcare professional. In addition, look out for severe side effects, such as: 

  • Vision changes 
  • Eye sensitivity to light 
  • Eye pain or swelling 
  • Eye discharge 
  • Irregular heartbeat 
  • Shortness of breath 
  • Pain or numbness in the extremities 
  • Fatigue 
  • Muscle weakness 
  • Unexplained weight gain 
  • Mental changes 

This is not a full or complete list of Combigan side effects. 


Before using this eye medication, disclose your medical history to your physician. This includes any history of irregular heartbeat, heart disease, lung disease, liver disease, kidney disease, orthostatic hypotension, blood circulation disorders, diabetes, hyperthyroidism, muscle weakness disorders, and depression. Some medical conditions may impact how your body will respond to the treatment. Moreover, talk to your doctor about all the prescription drugs, nonprescription drugs, and supplements you are taking, as they may have drug interactions with brimonidine or timolol. 

Watch out for an allergy while using this ophthalmic solution. Do not use this solution if you have a known allergic reaction to brimonidine, timolol, apraclonidine, or any inactive ingredients that this eye medication may contain. Stop using the medication and alert your local emergency line when a hypersensitivity reaction occurs. Signs are swelling of the face, red patches on the skin, hives, severe dizziness, and breathing difficulty. 

This medication may cause dizziness, drowsiness, and blurred vision. To avoid making these side effects worse, avoid alcoholic drinks or other beverages with similar substances. Practice caution when driving, using machinery, and doing any activities that require clear vision and alertness. 

Pregnant and/or breastfeeding mothers should only use this medication when clearly needed and with special precautions. 

Frequently Asked Questions 

How long will it take for Combigan to work? 

You may feel or notice the effects of this medication within one to two hours after use. 

Can Combigan cause low blood pressure? 

Hypotension is a rare adverse reaction to Combigan. However, it could cause dizziness and fainting. 

How should I store this medication? 

Put Combigan at room temperature and away from the sunlight. It should be properly disposed of if not consumed within 28 days. 

How much does this medication cost? 

You may check for Combigan prices from this page. 

Is this medication an OTC medication? 

You may check the pricing of this product by clicking here.

Brand Name:


Scientific Name:

Brimonidine Tartrate/Timolol Maleate

Other Names:

Brimocom, Combigan



Quantities Available:

5mL, 10mL, 15mL


Eye Drops

Maple Leaf Medications has provided information from third parties intended to increase awareness and does not contain all the information about Combigan (Brimonidine Tartrate/Timolol Maleate). Talk to your doctor or a qualified medical practitioner for medical attention, advice, or if you have any concerns about Combigan (Brimonidine Tartrate/Timolol Maleate).